Rabbit ANXA6 Polyclonal Antibody | anti-ANXA6 antibody
ANXA6 (Annexin A6, ANX6, CBP68) (AP)
WB: 1:500-1:2000
Applications are based on unconjugated antibody.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human thyroid cancer using ANXA6 antibody at dilution of 1:200 (200x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded mouse liver using ANXA6 antibody at dilution of 1:200 (200x lens).)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung using ANXA6 antibody at dilution of 1:200 (200x lens).)
NCBI and Uniprot Product Information
NCBI Description
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Uniprot Description
ANXA6: a calcium/phospholipid-binding protein that may associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Phosphorylated in response to growth factor stimulation. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Motility/polarity/chemotaxis; Calcium-binding; Lipid-binding
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: focal adhesion; membrane; lysosomal membrane; late endosome membrane; perinuclear region of cytoplasm; melanosome
Molecular Function: protein binding; protein homodimerization activity; GTP binding; calcium-dependent phospholipid binding; cholesterol binding; calcium ion binding; lipid binding; calcium-dependent protein binding; ligand-gated ion channel activity
Biological Process: regulation of muscle contraction; calcium ion transport; protein homooligomerization