Rabbit anti-Human PSMA8 Polyclonal Antibody | anti-PSMA8 antibody

PSMA8 (Proteasome Subunit alpha Type-7-like, PSMA7L, MGC26605) (HRP)

Cat. Num. AAA6391103

• Gene Names: PSMA8; PSMA7L
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PSMA8; Polyclonal Antibody; PSMA8 (Proteasome Subunit alpha Type-7-like; PSMA7L; MGC26605) (HRP); anti-PSMA8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PSMA8.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-PSMA8 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human PSMA8, aa1-250 (NP_001020267.1).
• Immunogen Sequence: MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGISRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDSEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKKKSKKSV
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PSMA8 expression in transfected 293T cell line by PSMA8 polyclonal antibody. Lane 1: PSMA8 transfected lysate (27.8kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-PSMA8 antibody

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This may be a testis-specific subunit.

Product Categories/Family for anti-PSMA8 antibody

Antibodies; Proteasomes

NCBI and Uniprot Product Information

• NCBI GI #: 68303563
• NCBI GeneID: 143471
• NCBI Accession #: NP_001020267.1
• NCBI GenBank Nucleotide #: NM_001025096.1
• UniProt Accession #: Q8TAA3; Q8IVP4; Q8TA98; Q8TAA2; B0YJ75
• Molecular Weight: 27,843 Da
• NCBI Official Full Name: proteasome subunit alpha type-7-like isoform 2
• NCBI Official Synonym Full Names: proteasome (prosome, macropain) subunit, alpha type, 8
• NCBI Official Symbol: PSMA8
• NCBI Official Synonym Symbols: PSMA7L
• NCBI Protein Information: proteasome subunit alpha type-7-like
• UniProt Protein Name: Proteasome subunit alpha type-7-like
• Protein Family: Proteasome
• UniProt Gene Name: PSMA8
• UniProt Synonym Gene Names: PSMA7L
• UniProt Entry Name: PSA7L_HUMAN

Uniprot Description

PSMA8: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This may be a testis-specific subunit. Belongs to the peptidase T1A family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.25.1; Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 18q11.2

Cellular Component: nucleus; cytosol

Molecular Function: threonine endopeptidase activity

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis