Rabbit anti-Human, Mouse ING4 Polyclonal Antibody | anti-ING4 antibody

ING4 (Inhibitor of Growth Protein 4, p29ING4, My036, MGC12557) (FITC)

Cat. Num. AAA6382896

• Gene Names: ING4; my036; p29ING4
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ING4; Polyclonal Antibody; ING4 (Inhibitor of Growth Protein 4; p29ING4; My036; MGC12557) (FITC); anti-ING4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ING4. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 1377

• Applicable Applications for anti-ING4 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human ING4, aa1-249 (AAH07781.1).
• Immunogen Sequence: MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ING4 rabbit polyclonal antibody. Western Blot analysis of ING4 expression in human liver.)

Western Blot (WB)

(ING4 rabbit polyclonal antibody. Western Blot analysis of ING4 expression in mouse kidney.)

Western Blot (WB)

(Western Blot analysis of ING4 expression in transfected 293T cell line by ING4 polyclonal antibody. Lane 1: ING4 transfected lysate (28.5kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-ING4 antibody

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Product Categories/Family for anti-ING4 antibody

Antibodies; Tumor Suppressors

NCBI and Uniprot Product Information

• NCBI GI #: 39645006
• NCBI GeneID: 51147
• NCBI Official Full Name: Homo sapiens inhibitor of growth family, member 4, mRNA
• NCBI Official Synonym Full Names: inhibitor of growth family member 4
• NCBI Official Symbol: ING4
• NCBI Official Synonym Symbols: my036; p29ING4
• NCBI Protein Information: inhibitor of growth protein 4
• Protein Family: Inhibitor of growth protein

NCBI Description

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]