Fms Active Protein | csf1ra active protein
Fms, Recombinant, Human (CD115, c-fms, CSF-1R, M-CSFR)
50% by SDS-PAGE
50% by SDS-PAGE
NCBI and Uniprot Product Information
Uniprot Description
Function: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Activates several signaling pathways in response to ligand binding
By similarity. Ref.1
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Enzyme regulation: Present in an inactive conformation in the absence of bound ligand. CSF1 binding leads to dimerization and activation by autophosphorylation on tyrosine residues
By similarity.
Subunit structure: Monomer. Homodimer. Interacts with CSF1
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein
By similarity. Note: The autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation
By similarity.
Domain: The juxtamembrane domain functions as autoinhibitory region. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase
By similarity.The activation loop plays an important role in the regulation of kinase activity. Phosphorylation of tyrosine residues in this region leads to a conformation change and activation of the kinase
By similarity.
Post-translational modification: Autophosphorylated in response to CSF1 binding
By similarity. autophosphorylation, leading to its degradation
By similarity.Ubiquitinated. Becomes rapidly polyubiquitinated after autophosphorylation, leading to its degradation
By similarity.
Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.
Research Articles on csf1ra
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Product Notes
The csf1ra csf1r (Catalog #AAA637946) is an Active Protein produced from Baculovirus infected Sf9 cells and is intended for research purposes only. The product is available for immediate purchase. Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Researchers should empirically determine the suitability of the csf1ra csf1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fms, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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