Proprotein Convertase 9 Human Active Protein | Pcsk9 active protein
Proprotein Convertase 9, Recombinant Human (PCSK9, Proprotein Convertase Subtilisin/Kexin Type 9, FH3, HCHOLA3, LDLCQ1, NARC1, NARC-1, Neural Apoptosis-regulated Convertase 1, PC9, PSEC0052, Subtilisin/kexin-like Protease PC9)
95% by SDSPAGE under reducing conditions and visualized by silver stain. Endotoxin: 1.0 EU/1ug (LAL)
95% by SDSPAGE under reducing conditions and visualized by silver stain. Endotoxin: 1.0 EU/1ug (LAL)
NCBI and Uniprot Product Information
Uniprot Description
PCSK9: Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. Defects in PCSK9 are the cause of hypercholesterolemia autosomal dominant type 3 (HCHOLA3). A familial condition characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.21.-; Secreted, signal peptide; Cell development/differentiation; Secreted
Cellular Component: Golgi apparatus; extracellular space; cell surface; rough endoplasmic reticulum; lysosome; endoplasmic reticulum; early endosome; extracellular region; ER to Golgi transport vesicle; perinuclear region of cytoplasm; late endosome; cytoplasm; plasma membrane; endosome
Molecular Function: peptidase activity; very-low-density lipoprotein binding; sodium channel inhibitor activity; protein self-association; low-density lipoprotein receptor binding; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; low-density lipoprotein binding; apolipoprotein binding; apolipoprotein receptor binding
Biological Process: steroid metabolic process; cholesterol metabolic process; lysosomal transport; apoptosis; positive regulation of receptor internalization; lipoprotein metabolic process; regulation of low-density lipoprotein receptor catabolic process; cellular response to starvation; proteolysis; neuron differentiation; protein autoprocessing; cholesterol homeostasis; triacylglycerol metabolic process; cellular response to insulin stimulus; phospholipid metabolic process; positive regulation of neuron apoptosis; regulation of neuron apoptosis; negative regulation of receptor recycling; protein processing; low-density lipoprotein receptor catabolic process; lipid metabolic process; regulation of receptor activity; low-density lipoprotein receptor metabolic process
Research Articles on Pcsk9
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Product Notes
The Pcsk9 pcsk9 (Catalog #AAA637603) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. SDS-PAGE: 19kD and 66kD (reducing conditions). Researchers should empirically determine the suitability of the Pcsk9 pcsk9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Proprotein Convertase 9 Human, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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