DC-SIGNR7 Active Protein | CD209 active protein
DC-SIGNR7, Recombinant, Mouse (CD209g, Signr7, SIGN-R7, Dendritic cell-specific ICAM-3 grabbing nonintegrin related gene 7)
Gene Names
CD209; DC-SIGN
Purity
Purified~90% (SDSPAGE, reducing, silver stain) Endotoxin: 1EU/ug (LAL)
Synonyms
DC-SIGNR7; Recombinant; Mouse (CD209g; Signr7; SIGN-R7; Dendritic cell-specific ICAM-3 grabbing nonintegrin related gene 7); CD209 active protein
Purity/Purification
Purified
~90% (SDSPAGE, reducing, silver stain) Endotoxin: 1EU/ug (LAL)
~90% (SDSPAGE, reducing, silver stain) Endotoxin: 1EU/ug (LAL)
Form/Format
Supplied as a lyophilized powder in PBS. Reconstitute with 250ul PBS.
Application Notes
SDS-PAGE: 29-30kD, reducing conditions.
Biological Activity
Measured by the ability of the immobilized protein to support the adhesion of LS180 human colon adenocarcinoma cells. When 5x10e4 cells/well are added to rmSIGN-R7 coated plates (5ug/ml,100ul/well), approximately 70%-90% will adhere after 1 hour at 37 degree C.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for CD209 active protein
SIGNR7 (dendritic cell-specific ICAM-3 grabbing nonintegrin related gene 7), also known as CD209g, belongs to the family of C-type lectins that participate in innate immune responses by binding and clearing pathogens. SIGNR7 is one of several mouse proteins which are encoded by separate genes and exhibit structural and sequence homology to human DC-SIGN and DC-SIGNR. Mouse SIGNR7 is a type 2 membrane protein that consists of a 45aa cytoplasmic domain, a 22aa transmembrane segment, and a 188aa extracellular domain with a juxtamembrane neck region and a single carbohydrate recognition domain (CRD). Within the CRD, mouse SIGNR7 shares 44%-49% aa sequence identity with mouse SIGNR1, 2, 3, 4, and 5 and 81% with SIGNR8. It shares 44%-54% aa sequence identity with the CRD of bovine SIGNR7, human DC-SIGN, human DC-SIGNR, and rat DC-SIGN. A SIGNR7 ortholog has been described in cow but not in human. SIGNR7 binds both fucose and mannose residues and shows a distinct binding preference for the 6'-sulfo-sialyl Lewisx carbohydrate. Its interaction with mannosylated BSA is disrupted at low pH.
Product Categories/Family for CD209 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
21.9kD
NCBI Official Full Name
DC-SIGN-like protein
NCBI Official Synonym Full Names
CD209 molecule
NCBI Official Symbol
CD209
NCBI Official Synonym Symbols
DC-SIGN
NCBI Protein Information
CD209 antigen
Protein Family
Uniprot Description
Enzyme and pathway databasesReactome - a knowledgebase of biological pathways and processes<br/><a href='/database/88'>More..</a>ReactomeiR-BTA-5621575. CD209 (DC-SIGN) signaling.
Research Articles on CD209
Similar Products
Product Notes
The CD209 (Catalog #AAA637518) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. SDS-PAGE: 29-30kD, reducing conditions. Researchers should empirically determine the suitability of the CD209 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DC-SIGNR7, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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