VEGFC, Rat Active Protein | Vegfc active protein

VEGFC, Recombinant, Rat (Vascular Endothelial Growth Factor C, VEGF-C, Flt4 Ligand, Flt4-L, Vascular Endothelial Growth Factor-related Protein, VRP)

Cat. Num. AAA637230

• Purity: Highly Purified; ~90% (SDS-PAGE)
• Synonyms: VEGFC; Rat; Recombinant; Rat (Vascular Endothelial Growth Factor C; VEGF-C; Flt4 Ligand; Flt4-L; Vascular Endothelial Growth Factor-related Protein; VRP); Vegfc active protein

• Purity/Purification: Highly Purified; ~90% (SDS-PAGE)
• Form/Format: Supplied as a lyophillized powder. Reconstitute in 0.1% acetic acid to 0.1-1mg/ml.

• Biological Activity: Activity of VEGF-C will be tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED50 is 200ng/ml.
• Endotoxin Level: <0.1ng/ug
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with acetic acid. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for Vegfc active protein

VEGF-C (Vascular Endothelial Growth Factor-C) is a 129aa recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain.

Product Categories/Family for Vegfc active protein

Growth Factors; Cytokines; Growth Factors-VEGF

NCBI and Uniprot Product Information

• NCBI GI #: 16758992
• NCBI GeneID: 114111
• NCBI Accession #: NP_446105.1
• NCBI GenBank Nucleotide #: NM_053653.1
• UniProt Accession #: O35757; Q91ZE3
• Molecular Weight: ~15kD
• NCBI Official Full Name: vascular endothelial growth factor C
• NCBI Official Synonym Full Names: vascular endothelial growth factor C
• NCBI Official Symbol: Vegfc
• NCBI Protein Information: vascular endothelial growth factor C; VRP; VEGF-C; flt4-L; flt4 ligand; vascular endothelial growth factor-related protein
• UniProt Protein Name: Vascular endothelial growth factor C
• Protein Family: Vascular endothelial growth factor
• UniProt Gene Name: Vegfc
• UniProt Synonym Gene Names: VEGF-C; Flt4-L; VRP
• UniProt Entry Name: VEGFC_RAT

NCBI Description

platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth [RGD, Feb 2006]

Uniprot Description

VEGFC: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family.

Protein type: Secreted; Cell cycle regulation; Secreted, signal peptide; Cytokine; Motility/polarity/chemotaxis

Cellular Component: extracellular space; membrane

Molecular Function: growth factor activity; vascular endothelial growth factor receptor 3 binding; chemoattractant activity

Biological Process: response to drug; positive regulation of neuroblast proliferation; positive regulation of blood vessel endothelial cell migration; regulation of angiogenesis; positive regulation of protein amino acid autophosphorylation; induction of positive chemotaxis; negative regulation of cell proliferation; positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; morphogenesis of embryonic epithelium; positive regulation of protein secretion; positive chemotaxis; positive regulation of cell division; regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell proliferation; angiogenesis; negative regulation of blood pressure; positive regulation of cell-matrix adhesion; vascular endothelial growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation