Rabbit anti-Human AHSA1 Polyclonal Antibody | anti-AHSA1 antibody

AHSA1 (Activator of 90kD Heat Shock Protein ATPase Homolog 1, AHA1, p38, HSPC322, C14orf3) (AP)

Cat. Num. AAA6369121

• Gene Names: AHSA1; p38; AHA1; hAha1; C14orf3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: AHSA1; Polyclonal Antibody; AHSA1 (Activator of 90kD Heat Shock Protein ATPase Homolog 1; AHA1; p38; HSPC322; C14orf3) (AP); anti-AHSA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human AHSA1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 1337

• Applicable Applications for anti-AHSA1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full-length human AHSA1, aa1-338 (NP_036243.1).
• Immunogen Sequence: MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of AHSA1 expression in transfected 293T cell line by AHSA1 polyclonal antibody. Lane 1: AHSA1 transfected lysate (38.3kD). Lane 2: Non-transfected lysate. )

Related Product Information for anti-AHSA1 antibody

Aha1 is a member of the Hsp90 cochaperone family, and is thought to stimulate Hsp90 ATPase activity by competing with p23 and other co-chaperones for Hsp90 binding. It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/Hsp90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors.

Product Categories/Family for anti-AHSA1 antibody

Antibodies; Heat Shock Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 1519242014
• NCBI GeneID: 10598
• NCBI Accession #: NM_012111.3
• NCBI GenBank Nucleotide #: NM_012111
• UniProt Accession #: O95433
• NCBI Official Full Name: Homo sapiens activator of HSP90 ATPase activity 1 (AHSA1), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: activator of HSP90 ATPase activity 1
• NCBI Official Symbol: AHSA1
• NCBI Official Synonym Symbols: p38; AHA1; hAha1; C14orf3
• NCBI Protein Information: activator of 90 kDa heat shock protein ATPase homolog 1
• UniProt Protein Name: Activator of 90 kDa heat shock protein ATPase homolog 1
• Protein Family: Activator of 90 kDa heat shock protein ATPase
• UniProt Gene Name: AHSA1
• UniProt Synonym Gene Names: C14orf3; AHA1
• UniProt Entry Name: AHSA1_HUMAN

Uniprot Description

AHSA1: Cochaperone that stimulates HSP90 ATPase activity. May affect a step in the endoplasmic reticulum to Golgi trafficking. Belongs to the AHA1 family.

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: endoplasmic reticulum; cytoplasm; cytosol

Molecular Function: ATPase activator activity; protein binding; chaperone binding

Biological Process: positive regulation of ATPase activity; response to stress