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Butyrylcholinesterase Active Protein | BCHE active protein

Butyrylcholinesterase, Recombinant, Mouse (BCHE)

Gene Names
BCHE; E1; CHE1; CHE2
Purity
Highly Purified
95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.
Synonyms
Butyrylcholinesterase; Recombinant; Mouse (BCHE); BCHE active protein
Ordering
For Research Use Only!
Purity/Purification
Highly Purified
95%, as determined by SDS-PAGE under reducing conditions and visualized by silver stain.
Form/Format
Supplied as a lyophilized powder in 0.2um sterile-filtered solution of 25mM tris, 0.15 M NaCl, pH 7.5.
Activity
Measured by its ability to hydrolyze butyrylthiocholine. The specific activity, measured under the described conditions, is 75 nmol/min/ug.
Endotoxin Level
1.0 EU/1ug (LAL)
Preparation and Storage
12 months from date of receipt, 20 to 70 degree C as supplied.
1 month, 2 to 8 degree C under sterile conditions after reconstitution.
3 months, 20 to 70 degree C under sterile conditions after reconstitution.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Product Categories/Family for BCHE active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
590
UniProt Accession #
Molecular Weight
The purified, secreted rmBCHE has a N-terminal sequence, H28TEEDFIITT. The 582 amino acid residue rmBCHE predicts a molecular mass of 66kD. By SDS-PAGE under reducing conditions,
the protein migrates with a molecular mass of approximately 86kD.
NCBI Official Full Name
butyrylcholinesterase
NCBI Official Synonym Full Names
butyrylcholinesterase
NCBI Official Symbol
BCHE
NCBI Official Synonym Symbols
E1; CHE1; CHE2
NCBI Protein Information
cholinesterase; cholinesterase 1; choline esterase II; pseudocholinesterase; butyrylcholine esterase; cholinesterase (serum) 2; acylcholine acylhydrolase
UniProt Protein Name
Cholinesterase
Protein Family
UniProt Gene Name
BCHE
UniProt Synonym Gene Names
CHE1
UniProt Entry Name
CHLE_HUMAN

NCBI Description

Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]

Uniprot Description

BCHE: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters. Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency). BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait. Belongs to the type-B carboxylesterase/lipase family.

Protein type: EC 3.1.1.8; Secreted; Hydrolase; Nuclear envelope; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q26.1-q26.2

Cellular Component: membrane; nuclear envelope lumen; endoplasmic reticulum lumen; extracellular region

Molecular Function: identical protein binding; choline binding; enzyme binding; cholinesterase activity; beta-amyloid binding; acetylcholinesterase activity; catalytic activity

Biological Process: response to alkaloid; response to drug; negative regulation of cell proliferation; cellular protein metabolic process; choline metabolic process; cocaine metabolic process; response to folic acid; response to glucocorticoid stimulus; neuroblast differentiation; learning; negative regulation of synaptic transmission

Research Articles on BCHE

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Product Notes

The BCHE bche (Catalog #AAA636806) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Butyrylcholinesterase, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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