Pigeon Versican ELISA Kit | VCAN elisa kit

Pigeon Versican ELISA Kit

• Gene Names: VCAN; WGN; ERVR; GHAP; PG-M; WGN1; CSPG2
• Reactivity: Pigeon
• Synonyms: Versican; Pigeon Versican ELISA Kit; VCAN elisa kit

• Reactivity: Pigeon
• Sequence Length: 3396

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 21361116
• NCBI GeneID: 1462
• NCBI Accession #: NP_004376.2
• NCBI GenBank Nucleotide #: NM_004385.4
• UniProt Accession #: P13611; P20754; Q13010; Q13189; Q15123; Q9UCL9; Q9UNW5
• Molecular Weight: 372,820 Da
• NCBI Official Full Name: versican core protein isoform 1
• NCBI Official Synonym Full Names: versican
• NCBI Official Symbol: VCAN
• NCBI Official Synonym Symbols: WGN; ERVR; GHAP; PG-M; WGN1; CSPG2
• NCBI Protein Information: versican core protein; versican proteoglycan; large fibroblast proteoglycan; glial hyaluronate-binding protein; chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan core protein 2
• UniProt Protein Name: Versican core protein
• Protein Family: Versican core protein
• UniProt Gene Name: VCAN
• UniProt Synonym Gene Names: CSPG2; Chondroitin sulfate proteoglycan 2; GHAP
• UniProt Entry Name: CSPG2_HUMAN

NCBI Description

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

CSPG2: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1). WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. Belongs to the aggrecan/versican proteoglycan family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q14.3

Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; proteinaceous extracellular matrix; intracellular membrane-bound organelle; membrane; Golgi lumen; extracellular region

Molecular Function: protein binding; glycosaminoglycan binding; extracellular matrix structural constituent; hyaluronic acid binding; calcium ion binding; carbohydrate binding

Biological Process: extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; multicellular organismal development; heart development; cell recognition; pathogenesis; glial cell migration; dermatan sulfate biosynthetic process; osteoblast differentiation; chondroitin sulfate metabolic process; chondroitin sulfate catabolic process; carbohydrate metabolic process; cell adhesion; skeletal development

Disease: Wagner Vitreoretinopathy