Rabbit anti-Human VIPR2 Polyclonal Antibody | anti-VIPR2 antibody
VIPR2, NT (VIPR2, VIP2R, Vasoactive intestinal polypeptide receptor 2, Helodermin-preferring VIP receptor, Pituitary adenylate cyclase-activating polypeptide type III receptor, VPAC2) (PE)
Gene Names
VIPR2; VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
VIPR2; Polyclonal Antibody; NT (VIPR2; VIP2R; Vasoactive intestinal polypeptide receptor 2; Helodermin-preferring VIP receptor; Pituitary adenylate cyclase-activating polypeptide type III receptor; VPAC2) (PE); VPAC2; anti-VIPR2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human VIPR2.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Applicable Applications for anti-VIPR2 antibody
Western Blot (WB), FLISA
Application Notes
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.
FLISA: 1:1,000
Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 95-123 in the N-terminal region of human VIPR2, UniProt Accession #P41587.
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of MBS643433 in Hela cell line lysates (35ug/lane). This demonstrates the VIPR2 antibody detected the VIPR2 protein (arrow).)
Related Product Information for anti-VIPR2 antibody
Vasoactive intestinal peptide (VIP; MIM 192320) and pituitary adenylate cyclase activating polypeptide (PACAP; MIM 102980) are homologous peptides that function as neurotransmitters and neuroendocrine hormones. While the receptors for VIP and PACAP share homology, they differ in their substrate specificities and expression patterns. See VIPR1 (MIM 192321) and ADCYAP1R1(MIM 102981).
Product Categories/Family for anti-VIPR2 antibody
References
1. Kovanen, L., et al. Alcohol Alcohol. 45(4):303-311(2010). 2. Kellogg, D.L. Jr., et al. J. Appl. Physiol. 109(1):95-100(2010). 3. Liu, Y.J., et al. Obesity (Silver Spring) (2010). 4. Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010). 5. Sjoholm, L.K., et al. J Circadian Rhythms 8, 1 (2010).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
49,479 Da
NCBI Official Full Name
vasoactive intestinal polypeptide receptor 2
NCBI Official Synonym Full Names
vasoactive intestinal peptide receptor 2
NCBI Official Symbol
VIPR2
NCBI Official Synonym Symbols
VPAC2; VPAC2R; VIP-R-2; VPCAP2R; PACAP-R3; DUP7q36.3; PACAP-R-3; C16DUPq36.3
NCBI Protein Information
vasoactive intestinal polypeptide receptor 2; PACAP type III receptor; VIP and PACAP receptor 2; helodermin-preferring VIP receptor; pituitary adenylate cyclase-activating polypeptide type III receptor
UniProt Protein Name
Vasoactive intestinal polypeptide receptor 2
Protein Family
UniProt Gene Name
VIPR2
UniProt Synonym Gene Names
VIP2R; VIP-R-2; PACAP type III receptor; PACAP-R-3; PACAP-R3
UniProt Entry Name
VIPR2_HUMAN
NCBI Description
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Uniprot Description
VIPR2: This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C. Belongs to the G-protein coupled receptor 2 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q36.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; vasoactive intestinal polypeptide receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; negative regulation of smooth muscle cell proliferation; adenylate cyclase activation; signal transduction
