Rabbit anti-Human TNIP2 Polyclonal Antibody | anti-TNIP2 antibody

TNIP2, ID (TNIP2, ABIN2, FLIP1, TNFAIP3-interacting protein 2, A20-binding inhibitor of NF-kappa-B activation 2, Fetal liver LKB1-interacting protein) (MaxLight 405)

Cat. Num. AAA6357114

• Gene Names: TNIP2; KLIP; ABIN2; FLIP1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TNIP2; Polyclonal Antibody; ID (TNIP2; ABIN2; FLIP1; TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2; Fetal liver LKB1-interacting protein) (MaxLight 405); Fetal liver LKB1-interacting protein; anti-TNIP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-TNIP2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TNIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-194 amino acids from the Central region of human TNIP2.
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-TNIP2 antibody

TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3; MIM 191163) and is involved in activation of the ERK (see MAPK3; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001 [PubMed 11390377]; Papoutsopoulou et al., 2006 [PubMed 16633345]).

Product Categories/Family for anti-TNIP2 antibody

Antibodies; Binding Proteins

References

Raychaudhuri, S., et al. Nat. Genet. 41(12):1313-1318(2009). Handoyo, H., et al. Biochem. J. 424(1):109-118(2009). Verstrepen, L., et al. Biochem. Pharmacol. 78(2):105-114(2009). Huang, L., et al. Oncogene 27(47):6131-6140(2008). Liu, Y., et al. J. Radiat. Res. 48(1):13-20(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 239787094
• NCBI GeneID: 79155
• NCBI Accession #: NP_001154999.1; NP_077285.3
• NCBI GenBank Nucleotide #: NM_001161527.1
• UniProt Accession #: Q8NFZ5; Q7L5L2; Q9BQR6; Q9H682; B1AKS4; B3KTY8; D3DVQ9
• Molecular Weight: 36,682 Da
• NCBI Official Full Name: TNFAIP3-interacting protein 2 isoform 2
• NCBI Official Synonym Full Names: TNFAIP3 interacting protein 2
• NCBI Official Symbol: TNIP2
• NCBI Official Synonym Symbols: KLIP; ABIN2; FLIP1
• NCBI Protein Information: TNFAIP3-interacting protein 2; TNIP2; fetal liver LKB1-interacting protein; A20-binding inhibitor of NF-kappaB activation-2
• UniProt Protein Name: TNFAIP3-interacting protein 2
• Protein Family: TNFAIP3-interacting protein
• UniProt Gene Name: TNIP2
• UniProt Synonym Gene Names: ABIN-2
• UniProt Entry Name: TNIP2_HUMAN

NCBI Description

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

Uniprot Description

TNIP2: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; polyubiquitin binding; protein kinase binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; protein stabilization; apoptosis; positive regulation of B cell activation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; toll-like receptor 3 signaling pathway; inflammatory response; positive regulation of macrophage activation; toll-like receptor 2 signaling pathway