Western Blot (WB)
(Western Blot analysis in mouse spleen tissue lysates (35ug/lane) usingMBS6003556. TM173 (arrow) was detected usingMBS6003556.)
Rabbit anti-Human TM173 Polyclonal Antibody | anti-TM173 antibody
TM173, CT (TMEM173, ERIS, MITA, STING, Transmembrane protein 173, Endoplasmic reticulum interferon stimulator, Mediator of IRF3 activation, Stimulator of interferon genes protein) (FITC)
Gene Names
TMEM173; ERIS; MITA; MPYS; NET23; STING
Reactivity
Human
Applications
Western Blot, Flow Cytometry, Functional Assay
Purity
Purified by Protein A and Peptide Affinity Chromatography.
Synonyms
TM173; Polyclonal Antibody; CT (TMEM173; ERIS; MITA; STING; Transmembrane protein 173; Endoplasmic reticulum interferon stimulator; Mediator of IRF3 activation; Stimulator of interferon genes protein) (FITC); TMEM173; Stimulator of interferon genes protein; anti-TM173 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human TM173.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Applicable Applications for anti-TM173 antibody
Western Blot (WB), Flow Cytometry (FC/FACS), FLISA
Application Notes
Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 311-340 in the C-terminal region of human TM173.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Western Blot (WB)
(Western Blot analysis in mouse spleen tissue lysates (35ug/lane) usingMBS6003556. TM173 (arrow) was detected usingMBS6003556.)
Western Blot (WB)
(Western Blot analysis in mouse spleen tissue lysates (35ug/lane) usingMBS6003556. TM173 (arrow) was detected usingMBS6003556.)
Flow Cytometry (FC/FACS)
(Flow Cytometric analysis in Hela cells using MBS6003556 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(Flow Cytometric analysis in Hela cells using MBS6003556 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Related Product Information for anti-TM173 antibody
TM173 acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Product Categories/Family for anti-TM173 antibody
References
1. Sun, W., et al. Proc. Natl. Acad. Sci. U.S.A. 106(21):8653-8658 (2009). 2. Zhong, B., et al. Immunity 30(3):397-407 (2009). 3. Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
379
NCBI Official Full Name
stimulator of interferon genes protein
NCBI Official Synonym Full Names
transmembrane protein 173
NCBI Official Symbol
TMEM173
NCBI Official Synonym Symbols
ERIS; MITA; MPYS; NET23; STING
NCBI Protein Information
stimulator of interferon genes protein; hMITA; hSTING; mediator of IRF3 activation; endoplasmic reticulum IFN stimulator; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine
UniProt Protein Name
Stimulator of interferon genes protein
UniProt Gene Name
TMEM173
UniProt Synonym Gene Names
ERIS; MITA; STING; hSTING; ERIS; hMITA
UniProt Entry Name
STING_HUMAN
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Product Notes
The TM173 tmem173 (Catalog #AAA6356001) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TM173, CT (TMEM173, ERIS, MITA, STING, Transmembrane protein 173, Endoplasmic reticulum interferon stimulator, Mediator of IRF3 activation, Stimulator of interferon genes protein) (FITC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TM173 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC/FACS), FLISA. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the TM173 tmem173 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TM173, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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