Rabbit anti-Human THBS3 Polyclonal Antibody | anti-THBS3 antibody

THBS3, NT (THBS3, TSP3, Thrombospondin-3) (MaxLight 405)

Cat. Num. AAA6355376

• Gene Names: THBS3; TSP3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: THBS3; Polyclonal Antibody; NT (THBS3; TSP3; Thrombospondin-3) (MaxLight 405); Thrombospondin-3; anti-THBS3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human THBS3.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-THBS3 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 227-255 in the N-terminal region of human THBS3, UniProt Accession #P49746. Species sequence homology: mouse
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in U251 cell line lysates (35ug/lane) usingMBS6004137. This demonstrates that MBS6004137 detected the THBS3 protein (arrow).)

Related Product Information for anti-THBS3 antibody

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1.

Product Categories/Family for anti-THBS3 antibody

Antibodies; Thrombospondin

References

1. Dalla-Torre, C.A., et al. BMC Cancer 6, 237 (2006). 2. Armstrong, D.J., et al. Int. J. Biochem. Cell Biol. 34(6):588-593(2002). 3. Carron, J.A., et al. Int. J. Biochem. Cell Biol. 32 (11-12), 1137-1142 (2000). 4. Adolph, K.W., et al. Mol. Cell Biol. Res. Commun. 2(1):47-52(1999). 5. Adolph, K.W. Biochem. Biophys. Res. Commun. 258(3):792-796(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 6005902
• NCBI GeneID: 7059
• NCBI Accession #: NP_009043.1
• NCBI GenBank Nucleotide #: NM_007112.4
• UniProt Accession #: P49746; Q8WV34; B1AVR8; B4DQ20
• Molecular Weight: 91,297 Da
• NCBI Official Full Name: thrombospondin-3 isoform 1
• NCBI Official Synonym Full Names: thrombospondin 3
• NCBI Official Symbol: THBS3
• NCBI Official Synonym Symbols: TSP3
• NCBI Protein Information: thrombospondin-3
• UniProt Protein Name: Thrombospondin-3
• Protein Family: Thrombospondin
• UniProt Gene Name: THBS3
• UniProt Synonym Gene Names: TSP3
• UniProt Entry Name: TSP3_HUMAN

NCBI Description

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

Uniprot Description

THBS3: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Belongs to the thrombospondin family.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: perinuclear region of cytoplasm; extracellular region

Molecular Function: heparin binding; calcium ion binding

Biological Process: cell-matrix adhesion