Rabbit anti-Human SOBP Polyclonal Antibody | anti-SOBP antibody

SOBP, CT (SOBP, JXC1, Sine oculis-binding protein homolog, Jackson circler protein 1) (Azide free) (HRP)

Cat. Num. AAA6349731

• Gene Names: SOBP; JXC1; MRAMS
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SOBP; Polyclonal Antibody; CT (SOBP; JXC1; Sine oculis-binding protein homolog; Jackson circler protein 1) (Azide free) (HRP); Jackson circler protein 1; anti-SOBP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-SOBP antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SOBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 839-869 amino acids from the C-terminal region of human SOBP.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SOBP Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the SOBP antibody detected the SOBP protein (arrow).)

Related Product Information for anti-SOBP antibody

Implicated in development of the cochlea (By similarity).

Product Categories/Family for anti-SOBP antibody

Antibodies; Binding Proteins

References

Rose, J. Phd, et al. Mol. Med. (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 117938310
• NCBI GeneID: 55084
• NCBI Accession #: NP_060483.3
• NCBI GenBank Nucleotide #: NM_018013.3
• UniProt Accession #: A7XYQ1; Q5BJD4; Q8N2B2; B0QZ12
• Molecular Weight: 92,658 Da
• NCBI Official Full Name: sine oculis-binding protein homolog
• NCBI Official Synonym Full Names: sine oculis binding protein homolog (Drosophila)
• NCBI Official Symbol: SOBP
• NCBI Official Synonym Symbols: JXC1; MRAMS
• NCBI Protein Information: sine oculis-binding protein homolog; jackson circler protein 1
• UniProt Protein Name: Sine oculis-binding protein homolog
• Protein Family: Sine oculis-binding protein
• UniProt Gene Name: SOBP
• UniProt Synonym Gene Names: JXC1
• UniProt Entry Name: SOBP_HUMAN

NCBI Description

The protein encoded by this gene is a nuclear zinc finger protein that is involved in development of the cochlea. Defects in this gene have also been linked to intellectual disability. [provided by RefSeq, Mar 2011]

Uniprot Description

Function: Implicated in development of the cochlea

By similarity.

Subunit structure: Interacts (via SIM domains) with SUMO1 and SUMO2. Ref.6

Involvement in disease: Mental retardation, anterior maxillary protrusion, and strabismus (MRAMS) [MIM:613671]: A syndrome characterized by severe mental retardation, strabismus and dysmorphic features such as anterior maxillary protrusion with vertical maxillary excess, open bite and prominent crowded teeth. Some patients may lack dysmorphic features and manifest temporal lobe epilepsy and psychosis. Esotropia and amblyopia are present in some individuals.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5

Sequence similarities: Belongs to the SOBP family.Contains 2 FCS-type zinc fingers.

Sequence caution: The sequence AAH91526.2 differs from that shown. Reason: Intron retention.The sequence BAC03537.1 differs from that shown. Reason: Intron retention.