Sm/RNP Antigen Protein | SNURF protein

Sm/RNP Antigen

Cat. Num. AAA634961

• Applications: ELISA
• Purity: Affinity Purified; 90% (SDS-PAGE); Purified by immunoaffinity chromatography.
• Synonyms: Sm/RNP Antigen; SNURF protein

• Host: Calf thymus
• Purity/Purification: Affinity Purified; 90% (SDS-PAGE); Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in 20mM Tris-HCI, 0.32M sodium chloride, 10mM magnesium chloride, 0.2mM DTT, pH 7.4, 0.1mM PMSF, 20% glycerol, 0.1% bromo-nitro-dioxane/ methylisothiazoline.

• Applicable Applications for SNURF protein: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 0.5-1.0ug/ml coating concentration.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for SNURF protein

Heterogeneous nuclear ribonucleoproteins (hnRNP) bind to nascent RNA polymerase II transcripts and are involved in transcript-specific packaging as well as alternative splicing of pre-mRNAs. hnRNPs also appear to influence mRNA metabolism and transport. In vivo, the M proteins bind to mRNA, and in vitro they bind avidly to poly(G) and poly(U) homopolymers. Four different isoforms of hnRNP are produced by alternative splicing: M1, M2, M3, and M4. Ongoing studies have theorized that hnRNPs may cause certain genetic diseases such as myotonic dystrophy, which is the most common form of adult muscular dystrophy. The identification of hnRNPs may therefore be important to determining the cause and cure for genetic diseases.

Product Categories/Family for SNURF protein

Molecular Biology; MB-Serum Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 13027653
• NCBI GeneID: 8926
• NCBI Accession #: NP_005669.2
• NCBI GenBank Nucleotide #: NM_005678.3
• UniProt Accession #: Q9Y675; A6NCW2
• Molecular Weight: 8,412 Da
• NCBI Official Full Name: SNRPN upstream reading frame protein
• NCBI Official Synonym Full Names: SNRPN upstream reading frame
• NCBI Official Symbol: SNURF
• NCBI Protein Information: SNRPN upstream reading frame protein
• UniProt Protein Name: SNRPN upstream reading frame protein
• Protein Family: SNRPN upstream reading frame protein
• UniProt Gene Name: SNURF
• UniProt Entry Name: SNURF_HUMAN

NCBI Description

This gene encodes a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known. [provided by RefSeq, Jul 2008]

Uniprot Description

SNURF: a highly basic 71-aa nuclear protein. Encoded with SNRPN on a polycistronic transcript. Play an important role in maintaining differentialy methylated DNA. The gene is imprinted, and disruption of imprinting plays a role in Prader-Willi syndrome (PWS). Translated in normal, but not PWS, human, and mouse tissues.

Protein type: Transcription regulation; Gene silencing

Chromosomal Location of Human Ortholog: 15q12

Cellular Component: nucleus