Rabbit anti-Human SNX17 Polyclonal Antibody | anti-SNX17 antibody

SNX17, NT (SNX17, KIAA0064, Sorting nexin-17) (Biotin)

Cat. Num. AAA6349542

• Gene Names: SNX17; KIAA0064
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SNX17; Polyclonal Antibody; NT (SNX17; KIAA0064; Sorting nexin-17) (Biotin); Sorting nexin-17; anti-SNX17 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-SNX17 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SNX17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from the N-terminal region of human SNX17.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SNX17 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SNX17 antibody detected the SNX17 protein (arrow).)

Related Product Information for anti-SNX17 antibody

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. [provided by RefSeq].

Product Categories/Family for anti-SNX17 antibody

Antibodies; SNX (Sorting Nexin) Proteins

References

Lee, J., et al. J. Biol. Chem. 283(17):11501-11508(2008). Wu, C., et al. Proteomics 7(11):1775-1785(2007). Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007). Czubayko, M., et al. Biochem. Biophys. Res. Commun. 345(3):1264-1272(2006). van Kerkhof, P., et al. EMBO J. 24(16):2851-2861(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 7661890
• NCBI GeneID: 9784
• NCBI Accession #: NP_055563.1
• NCBI GenBank Nucleotide #: NM_014748.2
• UniProt Accession #: Q15036; Q53HN7; Q6IAS3
• Molecular Weight: 52,901 Da
• NCBI Official Full Name: sorting nexin-17
• NCBI Official Synonym Full Names: sorting nexin 17
• NCBI Official Symbol: SNX17
• NCBI Official Synonym Symbols: KIAA0064
• NCBI Protein Information: sorting nexin-17; OTTHUMP00000123418
• UniProt Protein Name: Sorting nexin-17
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX17
• UniProt Synonym Gene Names: KIAA0064

Uniprot Description

Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).