Related Product Information for anti-SIPA1 antibody
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Product Categories/Family for anti-SIPA1 antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Brooks, R., et al. Gynecol. Oncol. 116(3):539-543(2010). Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Hsieh, S.M., et al. Breast Cancer Res. 11 (5), R75 (2009).
NCBI Description
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Uniprot Description
SIPA1: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
Protein type: GAPs, Ras; GAPs
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: Golgi apparatus; transport vesicle; protein complex; perinuclear region of cytoplasm; nucleolus; plasma membrane; cytosol; nucleus
Molecular Function: protein C-terminus binding; protein binding; GTPase activator activity
Biological Process: cell proliferation; cellular response to water deprivation; cytoskeleton organization and biogenesis; negative regulation of cell adhesion; negative regulation of cell growth; signal transduction; negative regulation of cell cycle; positive regulation of GTPase activity
Product Notes
The SIPA1 sipa1 (Catalog #
AAA6347739) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIPA1, CT (SIPA1, SPA1, Signal-induced proliferation-associated protein 1, GTPase-activating protein Spa-1, p130 SPA-1) (FITC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SIPA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SIPA1 sipa1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"SIPA1, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
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responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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of any product performance
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