Rabbit anti-Human SAP30L Polyclonal Antibody | anti-SAP30L antibody

SAP30L, ID (SAP30L, NS4ATP2, Histone deacetylase complex subunit SAP30L, HCV non-structural protein 4A-transactivated protein 2, Sin3 corepressor complex subunit SAP30L, Sin3-associated protein p30-like) (AP)

Cat. Num. AAA6345019

• Gene Names: SAP30L; NS4ATP2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SAP30L; Polyclonal Antibody; ID (SAP30L; NS4ATP2; Histone deacetylase complex subunit SAP30L; HCV non-structural protein 4A-transactivated protein 2; Sin3 corepressor complex subunit SAP30L; Sin3-associated protein p30-like) (AP); Sin3-associated protein p30-like; anti-SAP30L antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-SAP30L antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SAP30L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-134 amino acids from the Central region of human SAP30L.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SAP30L Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SAP30L antibody detected the SAP30L protein (arrow).)

Related Product Information for anti-SAP30L antibody

SAP30L is involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus.

Product Categories/Family for anti-SAP30L antibody

Antibodies; Histones

References

Silva, L.K., et al. Eur. J. Hum. Genet. (2010). In press: Viiri, K.M., et al. Mol. Cell. Biol. 29(2):342-356(2009). Korkeamaki, H., et al. FEBS Lett. 582(2):379-384(2008). Assmann, E.M., et al. J. Biol. Chem. 281(15):9869-9881(2006). Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 197099936
• NCBI GeneID: 79685
• NCBI Accession #: NP_001124534.1
• NCBI GenBank Nucleotide #: NM_001131062.1
• UniProt Accession #: Q9HAJ7; E9PAU7; E9PAY2
• Molecular Weight: 16,039 Da
• NCBI Official Full Name: histone deacetylase complex subunit SAP30L isoform 2
• NCBI Official Synonym Full Names: SAP30-like
• NCBI Official Symbol: SAP30L
• NCBI Official Synonym Symbols: NS4ATP2
• NCBI Protein Information: histone deacetylase complex subunit SAP30L
• UniProt Protein Name: Histone deacetylase complex subunit SAP30L
• Protein Family: Histone deacetylase complex
• UniProt Gene Name: SAP30L
• UniProt Synonym Gene Names: NS4ATP2

Uniprot Description

Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676).