Rabbit anti-Human PSG2 Polyclonal Antibody | anti-PSG2 antibody

PSG2, CT (PSG2, PSBG2, Pregnancy-specific beta-1-glycoprotein 2, Pregnancy-specific beta-1 glycoprotein E) (Biotin)

Cat. Num. AAA6338053

• Gene Names: PSG2; CEA; PSG1; PSBG2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PSG2; Polyclonal Antibody; CT (PSG2; PSBG2; Pregnancy-specific beta-1-glycoprotein 2; Pregnancy-specific beta-1 glycoprotein E) (Biotin); Pregnancy-specific beta-1 glycoprotein E; anti-PSG2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-PSG2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-254 amino acids from the C-terminal region of human PSG2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PSG2 Antibody (C-term) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the PSG2 antibody detected the PSG2 protein (arrow).)

Related Product Information for anti-PSG2 antibody

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).

Product Categories/Family for anti-PSG2 antibody

Antibodies; Carbohydrates; Glycoproteins

References

Tsavaris, N., et al. J Chemother 21(6):673-680(2009). Mennuni, C., et al. Int. J. Cancer 117(3):444-455(2005). Colland, F., et al. Genome Res. 14(7):1324-1332(2004). Grimwood, J., et al. Nature 428(6982):529-535(2004). Teglund, S., et al. Genomics 23(3):669-684(1994).

NCBI and Uniprot Product Information

• NCBI GI #: 156616282
• NCBI GeneID: 5670
• NCBI Accession #: NP_112536.2
• NCBI GenBank Nucleotide #: NM_031246.3
• UniProt Accession #: P11465; Q8TCD9; Q9UEA4; Q9UQ78
• Molecular Weight: 37,216 Da
• NCBI Official Full Name: pregnancy-specific beta-1-glycoprotein 2
• NCBI Official Synonym Full Names: pregnancy specific beta-1-glycoprotein 2
• NCBI Official Symbol: PSG2
• NCBI Official Synonym Symbols: CEA; PSG1; PSBG2
• NCBI Protein Information: pregnancy-specific beta-1-glycoprotein 2
• UniProt Protein Name: Pregnancy-specific beta-1-glycoprotein 2
• Protein Family: Pregnancy-specific beta-1-glycoprotein
• UniProt Gene Name: PSG2
• UniProt Synonym Gene Names: PSBG2; PS-beta-G-2; PSBG-2; Pregnancy-specific glycoprotein 2; PS-beta-E

NCBI Description

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Uniprot Description

PSG2: Belongs to the immunoglobulin superfamily. CEA family

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.31

Cellular Component: extracellular region

Biological Process: cell migration; female pregnancy