Rabbit anti-Human PF4V1 Polyclonal Antibody | anti-PF4V1 antibody

PF4V1, CT (PF4V1, CXCL4V1, SCYB4V1, Platelet factor 4 variant, C-X-C motif chemokine 4 variant, CXCL4L1, PF4alt, PF4var1, Platelet factor 4 variant(4-74), Platelet factor 4 variant(5-74), Platelet factor 4 variant(6-74)) (PE)

Cat. Num. AAA6332836

• Gene Names: PF4V1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PF4V1; Polyclonal Antibody; CT (PF4V1; CXCL4V1; SCYB4V1; Platelet factor 4 variant; C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1; Platelet factor 4 variant(4-74); Platelet factor 4 variant(5-74); Platelet factor 4 variant(6-74)) (PE); Platelet factor 4 variant(6-74); anti-PF4V1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PF4V1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-PF4V1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 77-104 in the C-terminal region of human PF4V1, UniProt Accession #NP_002611.1; P10720
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis in NCI-H460 cell line lysates (35ug/lane) usingMBS649442. This demonstrates MBS649442 detected the PF4V1 protein (arrow).)

Related Product Information for anti-PF4V1 antibody

PF4V1 is an inhibitor of angiogenesis and endothelial cell chemotaxis (in vitro).

Product Categories/Family for anti-PF4V1 antibody

Antibodies; Growth Factors; Cytokines

References

Davila, S., et al. Genes Immun. 11(3):232-238(2010). Hillian, A.D., et al. Genes Immun. 9(6):501-508(2008). Struyf, S., et al. Circ. Res. 95(9):855-857(2004). Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003). Eisman, R., et al. Blood 76(2):336-344(1990).

NCBI and Uniprot Product Information

• NCBI GI #: 4505735
• NCBI GeneID: 5197
• NCBI Accession #: NP_002611.1
• NCBI GenBank Nucleotide #: NM_002620.2
• UniProt Accession #: P10720; A1L4S0
• Molecular Weight: 11,553 Da
• NCBI Official Full Name: platelet factor 4 variant
• NCBI Official Synonym Full Names: platelet factor 4 variant 1
• NCBI Official Symbol: PF4V1
• NCBI Official Synonym Symbols: PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
• NCBI Protein Information: platelet factor 4 variant; PF4alt; PF4var1; C-X-C motif chemokine 4; platelet factor 4, variant 1 (PF4-like)
• UniProt Protein Name: Platelet factor 4 variant
• Protein Family: Platelet factor
• UniProt Gene Name: PF4V1
• UniProt Synonym Gene Names: CXCL4V1; SCYB4V1
• UniProt Entry Name: PF4V_HUMAN

Uniprot Description

PF4V1: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Chemokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q12-q21

Cellular Component: extracellular space

Molecular Function: heparin binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; regulation of cell proliferation