Mouse anti-Human GLUT3 Monoclonal Antibody | anti-SLC2A3 antibody

GLUT3 (Solute Carrier Family 2, Facilitated Glucose Transporter Member 3, Glucose Transporter Type 3, Brain, GLUT-3, SLC2A3)

Cat. Num. AAA633104

• Gene Names: SLC2A3; GLUT3
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Affinity Purified; Purified by Protein A/G affinity chromatography.
• Synonyms: GLUT3; Monoclonal Antibody; GLUT3 (Solute Carrier Family 2; Facilitated Glucose Transporter Member 3; Glucose Transporter Type 3; Brain; GLUT-3; SLC2A3); Anti -GLUT3 (Solute Carrier Family 2; anti-SLC2A3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 11C103
• Specificity: Recognizes human Glut-3.
• Purity/Purification: Affinity Purified; Purified by Protein A/G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.5. No preservative added.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-SLC2A3 antibody: Flow Cytometry (FC/FACS)
• Application Notes: Suitable for use in Flow Cytometry.; Dilution: Flow Cytometry: ~10ug/ml labels 10e6 cells. Perform the antibody binding in small volume of ~200ul.; Optimal dilutions to be determined by the researcher.
• Immunogen: Recombinant corresponding to human GLUT3. Eptitope: Extraceulluar.
• Preparation and Storage: May be stored at 4 degree C for short term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SLC2A3 antibody

Most mammalian cells transport glucose through a family of membrane proteins known as glucose transporters. Molecular cloning of these glucose transporters has identified a family of closely related genes that encodes at least 7 proteins (Glut-1 to Glut-13, Mol. Wt. 40-80kD) and Sodium glucose co-transporter-1 (SGLT-1, 662aa; ~75kD). Individual member of this family have identical predicted secondary structures with 12 transmembrane domains. Both N and C-termini are predicted to be cytoplasmic. Most differences in sequence homology exist within the four hydrophilic domains that may play a role in tissue-specific targeting. Glut isoforms differ in their tissue expression, substrate specificity and kinetic characteristics.

GLUT3 (human 496aa, mouse 493aa) is the main transporter in neurons, whereas Glut-4 is primarily expressed in muscle and adipose tissue and regulated by insulin.

Product Categories/Family for anti-SLC2A3 antibody

Antibodies; Abs to Glucose Transporters

NCBI and Uniprot Product Information

• NCBI GI #: 14268548
• NCBI GeneID: 6515
• UniProt Accession #: P11169; Q6I9U2; Q9UG15; B2R606; D3DUU6
• NCBI Official Full Name: glucose transporter-like protein III
• NCBI Official Synonym Full Names: solute carrier family 2 (facilitated glucose transporter), member 3
• NCBI Official Symbol: SLC2A3
• NCBI Official Synonym Symbols: GLUT3
• NCBI Protein Information: solute carrier family 2, facilitated glucose transporter member 3; GLUT-3; glucose transporter type 3, brain
• UniProt Protein Name: Solute carrier family 2, facilitated glucose transporter member 3
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC2A3
• UniProt Synonym Gene Names: GLUT3; GLUT-3
• UniProt Entry Name: GTR3_HUMAN

Uniprot Description

GLUT3: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. It???s surface expression is induced by insulin. It is restricted in humans to brain, testis (in the spermatozoa), and skeletal muscle, mostly in triads of slow-twitch fibres. Detected only in the brain of mouse and rat. IHC demonstrates its present in neurons, mainly at the plasma membrane, and to a lesser extent on intracellular vesicles distinct from synaptic vesicles. Present in the a-granules of human platelets, where it is translocated to the cell surface in response to thrombin stimulation. Its surface expression is increased by insulin or insulin growth-factor in cultured L6 muscle cells.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: glucose transmembrane transporter activity

Biological Process: vitamin metabolic process; hexose transport; carbohydrate metabolic process; L-ascorbic acid metabolic process; pathogenesis; glucose transport; transmembrane transport; water-soluble vitamin metabolic process