Rabbit anti-Human, Mouse NEO1 Polyclonal Antibody | anti-NEO1 antibody

NEO1, ID (NEO1, IGDCC2, NGN, Neogenin, Immunoglobulin superfamily DCC subclass member 2) (MaxLight 750)

Cat. Num. AAA6324670

• Gene Names: NEO1; NGN; IGDCC2; NTN1R2
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: NEO1; Polyclonal Antibody; ID (NEO1; IGDCC2; NGN; Neogenin; Immunoglobulin superfamily DCC subclass member 2) (MaxLight 750); Immunoglobulin superfamily DCC subclass member 2; anti-NEO1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NEO1. Species CrossReactivity: mouse.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
• Sequence Length: 1461

• Applicable Applications for anti-NEO1 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 657-685 in the Central region of human NEO1. Species sequence homology: rat
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse spleen tissue lysates (35ug/lane) usingMBS6006496. This demonstrates that MBS6006496 detected the NEO1 protein (arrow).)

Related Product Information for anti-NEO1 antibody

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq].

Product Categories/Family for anti-NEO1 antibody

Antibodies; Proteins

References

1. Bradford, D., et al. J. Comp. Neurol. 518(16):3237-3253(2010). 2. Davila, S., et al. Genes Immun. 11(3):232-238(2010). 3. Zhang, A.S., et al. J. Biol. Chem. 284(34):22580-22589(2009). 4. Fujita, Y., et al. Cell Death Differ. 15(10):1593-1608(2008). 5. Zhang, A.S., et al. J. Biol. Chem. 283(25):17494-17502(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 157311649
• NCBI GeneID: 4756
• NCBI Accession #: NP_002490.2
• NCBI GenBank Nucleotide #: NP_002490.2
• UniProt Accession #: Q92859
• NCBI Official Full Name: neogenin isoform 1
• NCBI Official Synonym Full Names: neogenin 1
• NCBI Official Symbol: NEO1
• NCBI Official Synonym Symbols: NGN; IGDCC2; NTN1R2
• NCBI Protein Information: neogenin
• UniProt Protein Name: Neogenin
• Protein Family: Neogenin
• UniProt Gene Name: NEO1
• UniProt Synonym Gene Names: IGDCC2; NGN

NCBI Description

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Description

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.