Rabbit anti-Human MYRIP Polyclonal Antibody | anti-MYRIP antibody

MYRIP, CT (MYRIP, SLAC2C, Rab effector MyRIP, Exophilin-8, Myosin-VIIa-and Rab-interacting protein, Synaptotagmin-like protein lacking C2 domains C) (MaxLight 750)

Cat. Num. AAA6323570

• Gene Names: MYRIP; SLAC2C; SLAC2-C
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MYRIP; Polyclonal Antibody; CT (MYRIP; SLAC2C; Rab effector MyRIP; Exophilin-8; Myosin-VIIa-and Rab-interacting protein; Synaptotagmin-like protein lacking C2 domains C) (MaxLight 750); Synaptotagmin-like protein lacking C2 domains C; anti-MYRIP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-MYRIP antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: MYRIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 658-686 amino acids from the C-terminal region of human MYRIP.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-MYRIP antibody

Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity).

Product Categories/Family for anti-MYRIP antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

References

Rose, J. Phd, et al. Mol. Med. (2010). In press: Nightingale, T.D., et al. Blood 113(20):5010-5018(2009). Hayasaka, S., et al. Asian J. Androl. 10(4):561-568(2008). Goehring, A.S., et al. J. Biol. Chem. 282(45):33155-33167(2007). Wu, C., et al. Proteomics 7(11):1775-1785(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 59853352
• NCBI GeneID: 25924
• NCBI Accession #: NP_056275.2
• NCBI GenBank Nucleotide #: NM_015460.3
• UniProt Accession #: Q8NFW9; Q32M41; Q32M42; Q569F7; Q8IUF5; Q9Y3V4; B3KWM3; B3KWW4; B7Z2H1; B7Z9V3; G3XAI8
• Molecular Weight: 83,948 Da
• NCBI Official Full Name: rab effector MyRIP isoform a
• NCBI Official Synonym Full Names: myosin VIIA and Rab interacting protein
• NCBI Official Symbol: MYRIP
• NCBI Official Synonym Symbols: SLAC2C; SLAC2-C
• NCBI Protein Information: rab effector MyRIP; exophilin-8; Slp homologue lacking C2 domains; slp homolog lacking C2 domains c; myosin-VIIa- and Rab-interacting protein; synaptotagmin-like protein lacking C2 domains C; synaptotagmin-like protein homologue lacking C2 domains-c
• UniProt Protein Name: Rab effector MyRIP
• Protein Family: Rab effector
• UniProt Gene Name: MYRIP
• UniProt Synonym Gene Names: SLAC2C; SlaC2-c; Slp homolog lacking C2 domains c
• UniProt Entry Name: MYRIP_HUMAN

Uniprot Description

MYRIP: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3p22.1

Cellular Component: transport vesicle; photoreceptor outer segment; perinuclear region of cytoplasm; exocyst; melanosome; synapse; actin cytoskeleton

Molecular Function: protein binding; zinc ion binding; protein kinase A binding; actin binding; Rab GTPase binding

Biological Process: intracellular protein transport; positive regulation of insulin secretion