Rabbit anti-Human MRPL41 Polyclonal Antibody | anti-MRPL41 antibody

MRPL41, NT (MRPL41, BMRP, MRPL27, RPML27, 39S ribosomal protein L41, mitochondrial, 39S ribosomal protein L27 homolog, Bcl-2-interacting mitochondrial ribosomal protein L41, Cell proliferation-inducing gene 3 protein, MRP-L27 homolog) (PE)

Cat. Num. AAA6322207

• Gene Names: MRPL41; BMRP; PIG3; MRPL27; RPML27; MRP-L27
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MRPL41; Polyclonal Antibody; NT (MRPL41; BMRP; MRPL27; RPML27; 39S ribosomal protein L41; mitochondrial; 39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog) (PE); MRP-L27 homolog; anti-MRPL41 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-MRPL41 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: MRPL41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human MRPL41.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(MRPL41 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MRPL41 antibody detected the MRPL41 protein (arrow).)

Related Product Information for anti-MRPL41 antibody

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.

Product Categories/Family for anti-MRPL41 antibody

Antibodies; Mitochondrial Proteins

References

Kim, M.J., et al. Biochem. Biophys. Res. Commun. 338(2):1179-1184(2005). Yoo, Y.A., et al. Mol. Cell. Biol. 25(15):6603-6616(2005). Chintharlapalli, S.R., et al. J. Cell. Biochem. 94(3):611-626(2005). Humphray, S.J., et al. Nature 429(6990):369-374(2004). Zhang, Z., et al. Genomics 81(5):468-480(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 21265093
• NCBI GeneID: 64975
• NCBI Accession #: NP_115866.1
• NCBI GenBank Nucleotide #: NM_032477.2
• UniProt Accession #: Q8IXM3; Q96Q49
• Molecular Weight: 15,383 Da
• NCBI Official Full Name: 39S ribosomal protein L41, mitochondrial
• NCBI Official Synonym Full Names: mitochondrial ribosomal protein L41
• NCBI Official Symbol: MRPL41
• NCBI Official Synonym Symbols: BMRP; PIG3; MRPL27; RPML27; MRP-L27
• NCBI Protein Information: 39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; MRP-L27 homolog; proliferation-inducing gene 3; 39S ribosomal protein L27 homolog; cell proliferation-inducing gene 3 protein; bcl-2-interacting mitochondrial ribosomal protein L41
• UniProt Protein Name: 39S ribosomal protein L41, mitochondrial
• Protein Family: 39S ribosomal protein
• UniProt Gene Name: MRPL41
• UniProt Synonym Gene Names: BMRP; MRPL27; RPML27; L41mt; MRP-L41
• UniProt Entry Name: RM41_HUMAN

NCBI Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

Uniprot Description

MRPL41: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. Belongs to the ribosomal protein L41 family.

Protein type: RNA-binding; Mitochondrial

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: mitochondrion; mitochondrial inner membrane; ribonucleoprotein complex; mitochondrial large ribosomal subunit

Molecular Function: protein binding; structural constituent of ribosome

Biological Process: mitochondrial translation; translation; apoptosis; organelle organization and biogenesis; cell cycle