Rabbit anti-Human Metabotropic Glutamate Receptor 3 Polyclonal Antibody | anti-GRM3 antibody

Metabotropic Glutamate Receptor 3, CT (GRM3, GPRC1C, MGLUR3, Metabotropic glutamate receptor 3) (APC)

Cat. Num. AAA6320339

• Gene Names: GRM3; GLUR3; mGlu3; GPRC1C; MGLUR3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Metabotropic Glutamate Receptor 3; Polyclonal Antibody; CT (GRM3; GPRC1C; MGLUR3; Metabotropic glutamate receptor 3) (APC); GRM3; Metabotropic glutamate receptor 3; anti-GRM3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-GRM3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Metabotropic Glutamate Receptor 3 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 833~863 amino acids from the C-terminal region of human GPRC1C.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(GPRC1C Antibody (R841) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the GPRC1C antibody detected the GPRC1C protein (arrow).)

Related Product Information for anti-GRM3 antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 (also known as GPRC1C) while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM3 is mediated by a G-protein that inhibits adenylate cyclase activity.

Product Categories/Family for anti-GRM3 antibody

Antibodies; G Protein Receptors

References

Aronica, E., et al., Neuroscience 130(4):927-933 (2005). Egan, M.F., et al., Proc. Natl. Acad. Sci. U.S.A. 101(34):12604-12609 (2004). Yao, Y., et al., Biochem. Biophys. Res. Commun. 319(2):622-628 (2004). Aronica, E., et al., Eur. J. Neurosci. 17(10):2106-2118 (2003). Scherer, S.W., et al., Science 300(5620):767-772 (2003).

NCBI and Uniprot Product Information

• NCBI GI #: 76803803
• NCBI GeneID: 2913
• UniProt Accession #: Q14832; Q2PNZ6; Q75MV4; Q75N17; Q86YG6; Q8TBH9
• Molecular Weight: 879
• NCBI Official Full Name: Metabotropic glutamate receptor 3
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 3
• NCBI Official Symbol: GRM3
• NCBI Official Synonym Symbols: GLUR3; mGlu3; GPRC1C; MGLUR3
• NCBI Protein Information: metabotropic glutamate receptor 3; glutamate metabotropic receptor 3
• UniProt Protein Name: Metabotropic glutamate receptor 3
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM3
• UniProt Synonym Gene Names: GPRC1C; MGLUR3; mGluR3
• UniProt Entry Name: GRM3_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

Uniprot Description

mGluR3: metabotropic glutamate receptor 3, a G-protein coupled receptor for glutamate. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q21.1-q21.2

Cellular Component: presynaptic membrane; postsynaptic membrane; axon; integral to plasma membrane; postsynaptic density; dendritic spine; plasma membrane

Molecular Function: G-protein coupled receptor activity; group II metabotropic glutamate receptor activity; group III metabotropic glutamate receptor activity; calcium channel regulator activity; glutamate receptor activity

Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; negative regulation of adenylate cyclase activity; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway