Rabbit anti-Mouse Prostaglandin F2-alpha Receptor Polyclonal Antibody | anti-PTGFR antibody

Anti-Prostaglandin F2-alpha Receptor (PF2R, PGF Receptor, PGF2-alpha Receptor, Prostanoid FP Receptor, Ptgfr)

Cat. Num. AAA631219

• Gene Names: PTGFR; FP; MGC46203; MGC120498
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified
• Synonyms: Prostaglandin F2-alpha Receptor; Polyclonal Antibody; Anti-Prostaglandin F2-alpha Receptor (PF2R; PGF Receptor; PGF2-alpha Receptor; Prostanoid FP Receptor; Ptgfr); PF2R; Ptgfr; anti-PTGFR antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: Recognizes mouse PF2R.
• Purity/Purification: Affinity Purified
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA.
• Concentration: ~1mg/ml (varies by lot)

• Applicable Applications for anti-PTGFR antibody: ELISA; Western Blot
• Application Notes: Recommended Dilutions: ELISA: 0.5-1ug/ml; Western Blot: 1-10ug/ml
• Immunogen: Synthetic peptide corresponding to 18aa from CP3 of mouse PF2R (Accession #Q9D627) and a 19aa C-terminal (PF2R2) peptides of rat PF2R (Accession #P43118) (KLH).
• Source Information: Mouse
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.; Shipping Temperature: Blue Ice

Related Product Information for anti-PTGFR antibody

Prostanoids are the cyclooxygenase metabolites derived from C-20 unsaturated fatty acids (arachidonic acid) and include prostaglandin (PG) D2, PGE2, PGF2 alpha, PGI2, and thrombaxane (Tx) A2. Prostaglandin F(2-alpha) is involved in a number of physiologic processes. It serves as a potent luteolytic agent in many species, has been implicated as a modulator of intraocular pressure, and may be important in smooth muscle contraction in the uterus and elsewhere. Its effects on cells are mediated through specific interaction with prostaglandin receptors (PTGFRs, PTGF2- alpha or PF2R). Human PF2R is a 359aa (calculated mo wt of ~40kD). It has 7 putative transmembrane domains characteristic of the G protein-coupled receptors. As expected, expression studies of the cDNA in Xenopus oocytes and COS cells showed strongest binding to PGF(2- alpha). It has been, mapped the gene to 1p31.1. PF2R knockout mice are unable to deliver normal fetuses at term due to a lack of response to oxytocin. The mice also failed to show the decline in serum progesterone expected to precede parturition. However, if the mice had their ovaries removed at day 19 of pregnancy, normal delivery occurred. Therefore, parturition may be initiated when prostaglandin F(2-alpha) interacts with its receptor in ovarian luteal cells to induce luteolysis. Rat PF2R expression has been detected in astrocytes and whole brain and pregnant ovary.

Product Categories/Family for anti-PTGFR antibody

Abs to Prostaglandins

NCBI and Uniprot Product Information

• NCBI GI #: 88758606
• NCBI GeneID: 5737
• NCBI Accession #: NP_001034674.1
• NCBI GenBank Nucleotide #: NM_001039585.1
• UniProt Accession #: Q6RYQ6; P43088; Q4LEK1; Q71UN9
• Molecular Weight: 33,653 Da
• NCBI Official Full Name: prostaglandin F2-alpha receptor isoform b
• NCBI Official Synonym Full Names: prostaglandin F receptor (FP)
• NCBI Official Symbol: PTGFR
• NCBI Official Synonym Symbols: FP; MGC46203; MGC120498
• NCBI Protein Information: prostaglandin F2-alpha receptor; PGF receptor; OTTHUMP00000011218; OTTHUMP00000037508; PGF2 alpha receptor; PGF2-alpha receptor; prostanoid FP receptor; prostaglandin F2 alpha receptor; prostaglandin receptor (2-alpha)
• UniProt Protein Name: FP prostanoid receptor
• Protein Family: Prostaglandin F2-alpha receptor
• UniProt Gene Name: PTGFR
• UniProt Entry Name: Q6RYQ6_HUMAN