Rabbit anti-Human HAUS7 Polyclonal Antibody | anti-HAUS7 antibody

HAUS7, NT (HAUS7, UCHL5IP, UIP1, HAUS augmin-like complex subunit 7, 26S proteasome-associated UCH37-interacting protein 1, UCHL5-interacting protein, X-linked protein STS1769) (PE)

Cat. Num. AAA6305525

• Gene Names: HAUS7; UIP1; UCHL5IP
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HAUS7; Polyclonal Antibody; NT (HAUS7; UCHL5IP; UIP1; HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769) (PE); X-linked protein STS1769; anti-HAUS7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-HAUS7 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HAUS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human HAUS7.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(HAUS7 Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the HAUS7 antibody detected the HAUS7 protein (arrow).)

Related Product Information for anti-HAUS7 antibody

This gene encodes a protein identified by interaction with ubiquitin C-terminal hydrolase 37, which functions to edit polyubiquitin chains on ubiquitinated substrates. This protein is a subunit of the multisubunit augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis.

Product Categories/Family for anti-HAUS7 antibody

Antibodies; Proteasomes

References

Xin, X., et al. Genome Res. 19(7):1262-1269(2009). Lawo, S., et al. Curr. Biol. 19(10):816-826(2009). Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009). Chen, M.J., et al. Nucleic Acids Res. 35(8):2682-2694(2007). Hahn, Y., et al. Hum. Genet. 119 (1-2), 169-178 (2006).

NCBI and Uniprot Product Information

• NCBI GI #: 66346717
• NCBI GeneID: 55559
• NCBI Accession #: NP_059988.3
• NCBI GenBank Nucleotide #: NM_017518.7
• UniProt Accession #: Q99871; Q96HS8; Q9NP54; Q9UFH9; B4DUH6; D3DWT9
• Molecular Weight: 37,524 Da
• NCBI Official Full Name: HAUS augmin-like complex subunit 7
• NCBI Official Synonym Full Names: HAUS augmin-like complex, subunit 7
• NCBI Official Symbol: HAUS7
• NCBI Official Synonym Symbols: UIP1; UCHL5IP
• NCBI Protein Information: HAUS augmin-like complex subunit 7
• UniProt Protein Name: HAUS augmin-like complex subunit 7
• Protein Family: HAUS augmin-like complex
• UniProt Gene Name: HAUS7
• UniProt Synonym Gene Names: UCHL5IP; UIP1
• UniProt Entry Name: HAUS7_HUMAN

NCBI Description

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Uniprot Description

HAUS7: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Belongs to the HAUS7 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Deoxyribonuclease; EC 3.1.11.2

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: microtubule; centrosome; cytoplasm; plasma membrane; nucleolus; spindle

Molecular Function: thioesterase binding

Biological Process: mitosis; cell division; centrosome organization and biogenesis; spindle assembly