Rabbit anti-Human, Mouse GIPC1 Polyclonal Antibody | anti-GIPC1 antibody

GIPC1, NT (GIPC1, C19orf3, GIPC, RGS19IP1, PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, Tax interaction protein 2) (Biotin)

Cat. Num. AAA6302283

• Gene Names: GIPC1; NIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GIPC1; Polyclonal Antibody; NT (GIPC1; C19orf3; GIPC; RGS19IP1; PDZ domain-containing protein GIPC1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Tax interaction protein 2) (Biotin); Tax interaction protein 2; anti-GIPC1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GIPC1. Species crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
• Sequence Length: 333

• Applicable Applications for anti-GIPC1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 52-81 in the N-terminal region of human GIPC1, UniProt Accession #O14908. Species sequence homology: rat
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of U251 cell line lysates (35ug/lane) usingMBS6006913. This demonstrates the GIPC1 antibody detected the GIPC1 protein (arrow).)

Western Blot (WB)

(Western blot analysis of MBS6006913 in mouse bladder tissue lysates (35ug/lane) usingMBS6006913. This demonstrates the GIPC1 antibody detected the GIPC1 protein (arrow).)

Related Product Information for anti-GIPC1 antibody

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).

Product Categories/Family for anti-GIPC1 antibody

Antibodies; PDZ Domain

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Wu, D., et al. J. Biol. Chem. 285(37):28643-28650(2010). Razanskas, R., et al. Arch. Virol. 155(2):247-250(2010). Puri, C., et al. Oncogene 29(2):188-200(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 42544140
• NCBI GeneID: 10755
• NCBI Accession #: NP_974199.1; NP_974196.1
• NCBI GenBank Nucleotide #: NP_974199.1
• UniProt Accession #: O14908
• NCBI Official Full Name: PDZ domain-containing protein GIPC1 isoform 1
• NCBI Official Synonym Full Names: GIPC PDZ domain containing family member 1
• NCBI Official Symbol: GIPC1
• NCBI Official Synonym Symbols: NIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN
• NCBI Protein Information: PDZ domain-containing protein GIPC1
• UniProt Protein Name: PDZ domain-containing protein GIPC1
• Protein Family: PDZ domain-containing protein
• UniProt Gene Name: GIPC1
• UniProt Synonym Gene Names: C19orf3; GIPC; RGS19IP1; TIP-2
• UniProt Entry Name: GIPC1_HUMAN

NCBI Description

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]

Uniprot Description

GIPC1: May be involved in G protein-linked signaling. Belongs to the GIPC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Vesicle; GAPs, misc.; GAPs

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: synaptic vesicle; membrane; endocytic vesicle; cytoplasm; cytoplasmic membrane-bound vesicle; dendritic spine; vesicle membrane; dendritic shaft; cell cortex; cytosol; brush border

Molecular Function: protein binding; protein homodimerization activity; myosin binding; actin binding; receptor binding; PDZ domain binding

Biological Process: positive regulation of cytokinesis; synaptic transmission; G-protein coupled receptor protein signaling pathway; glutamate secretion; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein stability; endothelial cell migration; regulation of synaptic plasticity; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein targeting