Rabbit anti-Human SSB Polyclonal Antibody | anti-ssbA antibody

SSB, CT (Lupus La Protein, Sjoegren Syndrome Type B Antigen, SS-B, La Ribonucleoprotein, La Autoantigen)

Cat. Num. AAA629091

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified; Purified by ammonium sulfate precipitation.
• Synonyms: SSB; Polyclonal Antibody; CT (Lupus La Protein; Sjoegren Syndrome Type B Antigen; SS-B; La Ribonucleoprotein; La Autoantigen); Anti -SSB; anti-ssbA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SSB.
• Purity/Purification: Purified; Purified by ammonium sulfate precipitation.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-ssbA antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:1,000; Western Blot: 1:50-1:100
• Immunogen: Synthetic peptide selected from the C-terminal region of human SSB (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of SSB Antibody (C-term) in K562, Hela, 293 cell line lysates (35ug/lane). SSB (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with ELAVL1 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Related Product Information for anti-ssbA antibody

SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III -transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. This protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.

Product Categories/Family for anti-ssbA antibody

Antibodies; Abs to Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 586039
• NCBI GeneID: 937911
• UniProt Accession #: P37455
• Molecular Weight: 18,742 Da
• NCBI Official Full Name: Single-stranded DNA-binding protein ssb
• NCBI Official Symbol: ssbA
• NCBI Protein Information: single-stranded DNA-binding protein ssb
• UniProt Protein Name: Single-stranded DNA-binding protein ssb
• Protein Family: SSB protein
• UniProt Gene Name: ssb
• UniProt Synonym Gene Names: SSB
• UniProt Entry Name: SSB1_BACSU

Uniprot Description

Function: Essential for replication of the chromosome. It is also involved in DNA recombination and repair

By similarity. Binds ssDNA.

Subunit structure: Homotetramer. Ref.4

Developmental stage: Strongly expressed during the exponential growth phase. Ref.3

Induction: Induced by mitomycin C. Ref.3

Post-translational modification: Phosphorylated by YwqD, which increases ssDNA affinity; dephosphorylated by YwqE. Ref.4

Sequence similarities: Contains 1 SSB domain.