Rabbit anti-Human, Mouse CHAT Polyclonal Antibody | anti-CHAT antibody
CHAT, NT (CHAT, Choline O-acetyltransferase) (MaxLight 750)
FLISA: 1:1,000
WB: 1:50-100
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of CHAT Antibody (N-term) in NCI-H460 cell line lysates (35ug/lane).CHAT (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CHAT Antibody (N-term) in mouse liver tissue lysates (35ug/lane). CHAT (arrow) was detected using the purified Pab.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]
Uniprot Description
CHAT: an enzyme that catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Four alternative splice variants have been described.
Protein type: EC 2.3.1.6; Lipid Metabolism - glycerophospholipid; Acetyltransferase
Chromosomal Location of Human Ortholog: 10q11.2
Cellular Component: cell soma; mitochondrion; axon; cytoplasm; nucleus; cytosol
Molecular Function: choline O-acetyltransferase activity
Biological Process: rhythmic excitation; muscle development; neurotransmitter secretion; glycerophospholipid biosynthetic process; adult walking behavior; synaptic transmission; rhythmic behavior; phospholipid metabolic process; phosphatidylcholine biosynthetic process; dendrite development; neuromuscular synaptic transmission; establishment of synaptic specificity at neuromuscular junction; neurotransmitter biosynthetic process
Disease: Myasthenic Syndrome, Congenital, Associated With Episodic Apnea