Rabbit anti-Human CSNK1D Polyclonal Antibody | anti-CSNK1D antibody

CSNK1D, CT (Casein Kinase I, delta Isoform, CKI-delta, CKId)

Cat. Num. AAA628295

• Gene Names: CSNK1D; HCKID
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: CSNK1D; Polyclonal Antibody; CT (Casein Kinase I; delta Isoform; CKI-delta; CKId); Anti -CSNK1D; anti-CSNK1D antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CK1d.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-CSNK1D antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot, and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Western Blot: 1:100-1:500; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the C-terminal region of human CK1d (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-CK1d C-term Pab in HeLa cell lysate. CK1d (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)

Related Product Information for anti-CSNK1D antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The casein kinase 1 (CK1) group consists of 12 kinases including CK1, TTBK (tau tubulin kinase), and VRK (vaccinia-related kinase) families The receptor guanylate cyclase (RGC) group consists of 5 kinases similar in domain sequence to TKs (ANP, CYG).

Product Categories/Family for anti-CSNK1D antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 20149530
• NCBI GeneID: 1453
• NCBI Accession #: NP_001884.2
• NCBI GenBank Nucleotide #: NM_001893.4
• UniProt Accession #: P48730; Q96KZ6; Q9BTN5; A2I2P2; Q59FJ7
• Molecular Weight: 47,330 Da
• NCBI Official Full Name: casein kinase I isoform delta isoform 1
• NCBI Official Synonym Full Names: casein kinase 1, delta
• NCBI Official Symbol: CSNK1D
• NCBI Official Synonym Symbols: HCKID
• NCBI Protein Information: casein kinase I isoform delta; CKId; CKI-delta
• UniProt Protein Name: Casein kinase I isoform delta
• Protein Family: Casein kinase
• UniProt Gene Name: CSNK1D
• UniProt Entry Name: KC1D_HUMAN

NCBI Description

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

CK1D: an ubiquitous protein kinase of the CK1 family. Enriched at the centrosomes in interphase and at the spindle during mitosis. May play a role in cell cycle progression. Two splice variant isoforms have been described.

Protein type: EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CK1; EC 2.7.11.1; Kinase, protein; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: Golgi apparatus; centrosome; spindle microtubule; perinuclear region of cytoplasm; plasma membrane; spindle; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; phosphoprotein binding; glycoprotein binding; peptide binding; ATP binding; protein kinase activity

Biological Process: Wnt receptor signaling pathway; organelle organization and biogenesis; endocytosis; spindle assembly; DNA repair; signal transduction; regulation of circadian rhythm; protein amino acid phosphorylation; regulation of cell shape; peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; circadian regulation of gene expression; G2/M transition of mitotic cell cycle

Disease: Advanced Sleep Phase Syndrome, Familial, 2