Rabbit anti-Human CCR1 Polyclonal Antibody | anti-CCR1 antibody

CCR1, NT (CCR1, CMKBR1, CMKR1, SCYAR1, C-C chemokine receptor type 1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, RANTES-R, CD191) (MaxLight 750)

Cat. Num. AAA6282595

• Gene Names: CCR1; CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CCR1; Polyclonal Antibody; NT (CCR1; CMKBR1; CMKR1; SCYAR1; C-C chemokine receptor type 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; RANTES-R; CD191) (MaxLight 750); CD191; anti-CCR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-CCR1 antibody: Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; FLISA: 1:1,000; IHC: 1:50-100; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: CCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2~31 amino acids from the N-terminal region of human CCR1.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-CCR1 antibody

CCR1 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

Product Categories/Family for anti-CCR1 antibody

Antibodies; CD Markers

References

Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010). Anderson, M.W., et al. Am. J. Clin. Pathol. 133(3):473-483(2010). Amundsen, S.S., et al. Genes Immun. 11(1):79-86(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 4502631
• NCBI GeneID: 1230
• NCBI Accession #: NP_001286.1
• NCBI GenBank Nucleotide #: NM_001295.2
• UniProt Accession #: P32246; Q86VA9
• Molecular Weight: 41,173 Da
• NCBI Official Full Name: C-C chemokine receptor type 1
• NCBI Official Synonym Full Names: C-C motif chemokine receptor 1
• NCBI Official Symbol: CCR1
• NCBI Official Synonym Symbols: CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1
• NCBI Protein Information: C-C chemokine receptor type 1
• UniProt Protein Name: C-C chemokine receptor type 1
• Protein Family: C-C chemokine receptor
• UniProt Gene Name: CCR1
• UniProt Synonym Gene Names: CMKBR1; CMKR1; SCYAR1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; MIP-1alpha-R

NCBI Description

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.