Rabbit anti-Human THEM2 Polyclonal Antibody | anti-ACOT13 antibody

THEM2, NT (Acyl-coenzyme A Thioesterase 13, Acyl-CoA Thioesterase 13, Thioesterase Superfamily Member 2, ACOT13, HT012, PNAS-27)

Cat. Num. AAA627909

• Gene Names: ACOT13; HT012; THEM2; PNAS-27
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: THEM2; Polyclonal Antibody; NT (Acyl-coenzyme A Thioesterase 13; Acyl-CoA Thioesterase 13; Thioesterase Superfamily Member 2; ACOT13; HT012; PNAS-27); Anti -THEM2; anti-ACOT13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human THEM2.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-ACOT13 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Immunohistochemistry: 1:10-1:50
• Immunogen: Synthetic peptide selected from the N-terminal region of human THEM2 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-ACOT13 antibody

Human thioesterase superfamily member 2 (hTHEM2) belongs to the hotdog-fold enzyme superfamily. The encoding gene is highly expressed in the kidney, and moderately expressed in the liver, brain, large intestine, and small intestine. THEM2 is essential for cell sustained proliferation based on small interference RNA silencing studies. THEM2 co-localizes with microtubules in immunostaining and GFP-Tag experiments.

Product Categories/Family for anti-ACOT13 antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 119575864
• NCBI GeneID: 55856
• UniProt Accession #: Q9NPJ3; O95549; F5H2L4
• Molecular Weight: 14,960 Da
• NCBI Official Full Name: thioesterase superfamily member 2
• NCBI Official Synonym Full Names: acyl-CoA thioesterase 13
• NCBI Official Symbol: ACOT13
• NCBI Official Synonym Symbols: HT012; THEM2; PNAS-27
• NCBI Protein Information: acyl-coenzyme A thioesterase 13; hypothalamus protein HT012; thioesterase superfamily member 2
• UniProt Protein Name: Acyl-coenzyme A thioesterase 13
• Protein Family: Acyl-coenzyme A thioesterase
• UniProt Gene Name: ACOT13
• UniProt Synonym Gene Names: THEM2; Acyl-CoA thioesterase 13
• UniProt Entry Name: ACO13_HUMAN

NCBI Description

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

Uniprot Description

THEM2: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro). Belongs to the thioesterase PaaI family.

Protein type: EC 3.1.2.-

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: mitochondrion; spindle; cytosol; nucleus

Molecular Function: acyl-CoA hydrolase activity

Biological Process: metabolic process; protein homotetramerization