Rabbit anti-Human ANTXR1 Polyclonal Antibody | anti-ANTXR1 antibody
Anti-ANTXR1 (Anthrax Toxin Receptor 1, Tumor Endothelial Marker 8, ATR, TEM8)
Gene Names
ANTXR1; ATR; TEM8; FLJ10601; FLJ11298; FLJ21776
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity Purified
Synonyms
ANTXR1; Polyclonal Antibody; Anti-ANTXR1 (Anthrax Toxin Receptor 1; Tumor Endothelial Marker 8; ATR; TEM8); Anthrax Toxin Receptor 1; TEM8; anti-ANTXR1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human ATR-1.
Purity/Purification
Affinity Purified
Form/Format
Supplied as a liquid in PBS, 0.1% BSA.
Concentration
~1mg/ml (varies by lot)
Applicable Applications for anti-ANTXR1 antibody
ELISA; Western Blot
Application Notes
Recommended Dilutions: ELISA: 0.5-1ug/ml
Western Blot: 1-10ug/ml
Western Blot: 1-10ug/ml
Immunogen
Synthetic peptide corresponding to 14aa of human ATR-1.
Source Information
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Shipping Temperature: Blue Ice
Shipping Temperature: Blue Ice
Related Product Information for anti-ANTXR1 antibody
Anthrax toxin secreted by Bacillus anthracis, consists of three polypeptides: protective antigen (PA, 83kD) lethal factor (LF, 90kD) and oedma factor (OF, 89kD). The two components (OF and LF) of the toxin enzymatically modify substrates within the cytosol of the mammalian cells: The OF is an adenylate cyclase that impairs the host defenses through a variety of mechanisms inhibiting phagocytosis. The LF is a zinc dependent protease that cleaves mitogen activated protein kinase kinase (MAPKK) and causes lysis of macrophages. To intoxicate mammalian cells, the third component of the toxin PA, binds to a ubiquitously expressed cellular receptor, Tumor Endothelium Marker-8 (TEM8). Upon binding to TEM8, PA is cleaved into 20 and 63kD fragments (PA20 and PA63) by furin or furin-like proteases. PA63 fragment then forms a complex with LF and OF components of toxin leading to internalization and translocation of LF and OF into cytosol of the cells.
PA receptor TEM8 (also known as Anthrax Toxin receptor, ATR1) (human 564aa, mouse 562aa) is a glycoprotein with an extracellular (1-321aa), cytosolic (343-564aa) and TM (322-342) domains. The cytosolic domain is not required for translocation of LF into cytosol. The ATR/TEM8 gene is mapped at chromosome 4. Three splice variants (ATR1, ATR2 and ATR3) of TEM8/ATR have been reported. ATR1 (564aa) is the largest isoform whereas ATR2 (368aa) and ATR3 (333aa) are proteins truncated after the TM domain. The seqs (1-364aa) of ATR2 and ATR1 are identical whereas ATR3 has a unique 15aa seq at its C-terminal. ATR/TEM8 protein is expressed in a variety of cell lines and in heart, lung, lymphocytes and in central nervous system. The fact that Von Willebrand Factor Type A domain (VWA) (44-216aa) present in ATR -1, -2 and -3 by itself is able to interact inactivate anthrax toxin; ATR antibodies might help in developing new approaches for PA-receptor study and treatment of anthrax.
PA receptor TEM8 (also known as Anthrax Toxin receptor, ATR1) (human 564aa, mouse 562aa) is a glycoprotein with an extracellular (1-321aa), cytosolic (343-564aa) and TM (322-342) domains. The cytosolic domain is not required for translocation of LF into cytosol. The ATR/TEM8 gene is mapped at chromosome 4. Three splice variants (ATR1, ATR2 and ATR3) of TEM8/ATR have been reported. ATR1 (564aa) is the largest isoform whereas ATR2 (368aa) and ATR3 (333aa) are proteins truncated after the TM domain. The seqs (1-364aa) of ATR2 and ATR1 are identical whereas ATR3 has a unique 15aa seq at its C-terminal. ATR/TEM8 protein is expressed in a variety of cell lines and in heart, lung, lymphocytes and in central nervous system. The fact that Von Willebrand Factor Type A domain (VWA) (44-216aa) present in ATR -1, -2 and -3 by itself is able to interact inactivate anthrax toxin; ATR antibodies might help in developing new approaches for PA-receptor study and treatment of anthrax.
Product Categories/Family for anti-ANTXR1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,083 Da
NCBI Official Full Name
anthrax toxin receptor 1 isoform 3
NCBI Official Synonym Full Names
anthrax toxin receptor 1
NCBI Official Symbol
ANTXR1
NCBI Official Synonym Symbols
ATR; TEM8; FLJ10601; FLJ11298; FLJ21776
NCBI Protein Information
anthrax toxin receptor 1; 2310008J16Rik; 2810405N18Rik; OTTHUMP00000159975; OTTHUMP00000202140; OTTHUMP00000202171; tumor endothelial marker 8
UniProt Protein Name
Anthrax toxin receptor/neuroblastoma fusion protein transcript variant 3
Protein Family
UniProt Gene Name
ANTXR1/NNG1 fusion
UniProt Entry Name
Q508I6_HUMAN
Similar Products
Product Notes
The ANTXR1 antxr1/nng1 fusion (Catalog #AAA624941) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ANTXR1 (Anthrax Toxin Receptor 1, Tumor Endothelial Marker 8, ATR, TEM8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ANTXR1 can be used in a range of immunoassay formats including, but not limited to, ELISA; Western Blot. Recommended Dilutions: ELISA: 0.5-1ug/ml Western Blot: 1-10ug/ml. Researchers should empirically determine the suitability of the ANTXR1 antxr1/nng1 fusion for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ANTXR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
