Rabbit anti-Bovine Folate Binding Protein Polyclonal Antibody | anti-FOLR1 antibody

Folate Binding Protein

Cat. Num. AAA624697

• Gene Names: FOLR1; FBP; FOLR
• Reactivity: Bovine
• Applications: ELISA
• Purity: Serum; Neat serum
• Synonyms: Folate Binding Protein; Polyclonal Antibody; Anti -Folate Binding Protein; anti-FOLR1 antibody

• Host: Rabbit
• Reactivity: Bovine
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes bovine Folate Binding Protein.
• Purity/Purification: Serum; Neat serum
• Form/Format: Supplied as a liquid, 0.1% sodium azide.

• Applicable Applications for anti-FOLR1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Bovine milk
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-FOLR1 antibody

Folate Binding Protein, has a high affinity for folic acid and for several reduced folic acid derivatives and mediates delivery of 5 methyltetrahydrofolate to the interior of cells. Membrane bound and soluble forms of a high affinity folate binding protein have been found in kidney, placenta, serum, milk, and in several cell lines. The 2 forms have similar binding characteristics for folates, are immunologically crossreactive, and, based upon limited amino acid sequence data, are nearly identical. There may be a precursor product relationship between the membrane and soluble forms, the membrane form having additional amino acid residues and greater molecular weight. The membrane form has been shown to mediate the transport of folate in cells grown in physiologic concentrations of folate. A function for the soluble form, which is found in serum, milk, and urine, has not been identified.

Product Categories/Family for anti-FOLR1 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 9257213
• NCBI GeneID: 2348
• NCBI Accession #: NP_057941.1
• NCBI GenBank Nucleotide #: NM_016729.2
• UniProt Accession #: P15328; Q53EW2; Q6FGT8; Q6LC90; Q9UCT2
• Molecular Weight: 29,819 Da
• NCBI Official Full Name: folate receptor alpha
• NCBI Official Synonym Full Names: folate receptor 1 (adult)
• NCBI Official Symbol: FOLR1
• NCBI Official Synonym Symbols: FBP; FOLR
• NCBI Protein Information: folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18
• UniProt Protein Name: Folate receptor alpha
• Protein Family: Folate receptor
• UniProt Gene Name: FOLR1
• UniProt Synonym Gene Names: FOLR; FR-alpha; FBP
• UniProt Entry Name: FOLR1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

FOLR1: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain- specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Belongs to the folate receptor family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q13.3-q14.1

Cellular Component: anchored to external side of plasma membrane; cell surface; clathrin-coated vesicle; membrane; brush border membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; endosome

Molecular Function: folic acid transporter activity; receptor activity; folic acid binding

Biological Process: receptor-mediated endocytosis; folic acid metabolic process; folic acid transport

Disease: Neurodegeneration Due To Cerebral Folate Transport Deficiency