Mouse SYNE1 Monoclonal Antibody | anti-SYNE1 antibody

SYNE1 (spectrin Repeat Containing, Nuclear envelope 1, 8B, CPG2, DKFZp781J13156, FLJ30878, FLJ41140, KIAA0796, KIAA1262, KIAA1756, MYNE1, SCAR8) (MaxLight 750)

Cat. Num. AAA6240850

• Gene Names: SYNE1; 8B; AMCM; CPG2; ARCA1; EDMD4; KASH1; MYNE1; Nesp1; SCAR8; C6orf98; dJ45H2.2
• Applications: Western Blot
• Purity: Purified
• Synonyms: SYNE1; Monoclonal Antibody; SYNE1 (spectrin Repeat Containing; Nuclear envelope 1; 8B; CPG2; DKFZp781J13156; FLJ30878; FLJ41140; KIAA0796; KIAA1262; KIAA1756; MYNE1; SCAR8) (MaxLight 750); spectrin Repeat Containing; SCAR8; anti-SYNE1 antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG3,k
• Clone Number: 3G2
• Specificity: Recognizes SYNE1.
• Purity/Purification: Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
• Sequence Length: 8797

• Applicable Applications for anti-SYNE1 antibody: FLISA, Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: SYNE1 (NP_892006, 1561aa-1670aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
• Conjugate: MaxLight750
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-SYNE1 antibody

This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]

Product Categories/Family for anti-SYNE1 antibody

Antibodies; Nuclear Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 330688408
• NCBI GeneID: 23345
• NCBI Accession #: NP_892006
• NCBI GenBank Nucleotide #: NP_892006.3
• UniProt Accession #: Q8NF91
• NCBI Official Full Name: nesprin-1 isoform 1 (nesprin-1 giant or enaptin)
• NCBI Official Synonym Full Names: spectrin repeat containing nuclear envelope protein 1
• NCBI Official Symbol: SYNE1
• NCBI Official Synonym Symbols: 8B; AMCM; CPG2; ARCA1; EDMD4; KASH1; MYNE1; Nesp1; SCAR8; C6orf98; dJ45H2.2
• NCBI Protein Information: nesprin-1
• UniProt Protein Name: Nesprin-1
• Protein Family: Nesprin
• UniProt Gene Name: SYNE1
• UniProt Synonym Gene Names: C6orf98; KIAA0796; KIAA1262; KIAA1756; MYNE1; Myne-1; Syne-1
• UniProt Entry Name: SYNE1_HUMAN

NCBI Description

This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

SYNE1: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein- containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. May be involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F- actin in the cytoplasm. May be required for centrosome migration to the apical cell surface during early ciliogenesis. Defects in SYNE1 are the cause of spinocerebellar ataxia autosomal recessive type 8 (SCAR8); also known as autosomal recessive cerebellar ataxia type 1 (ARCA1) or recessive ataxia of Beauce. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR8 is an autosomal recessive form. Defects in SYNE1 are the cause of Emery-Dreifuss muscular dystrophy type 4 (EDMD4). A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows, Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects. Belongs to the nesprin family. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Membrane protein, integral; Actin-binding

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: nucleoplasm; Golgi apparatus; nuclear outer membrane; postsynaptic membrane; nuclear membrane; sarcomere; cytoskeleton; cytoplasm; integral to membrane; nuclear envelope; nucleus

Molecular Function: actin filament binding; protein binding; protein homodimerization activity; actin binding; lamin binding

Biological Process: muscle cell differentiation; establishment of nucleus localization; Golgi organization and biogenesis; nuclear organization and biogenesis

Disease: Emery-dreifuss Muscular Dystrophy 4, Autosomal Dominant; Spinocerebellar Ataxia, Autosomal Recessive 8