Rabbit Semaphorin 3B Polyclonal Antibody | anti-SEMA3B antibody

Semaphorin 3B (SEMA3B, Semaphorin V, Seam A(V), Sema V)

Cat. Num. AAA622831

• Gene Names: SEMA3B; SemA; SEMA5; SEMAA; semaV; LUCA-1; FLJ34863
• Reactivity: Human, Mouse0
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Semaphorin 3B; Polyclonal Antibody; Semaphorin 3B (SEMA3B; Semaphorin V; Seam A(V); Sema V); Anti -Semaphorin 3B (SEMA3B; anti-SEMA3B antibody

• Host: Rabbit
• Reactivity: Human, Mouse0
• Clonality: Polyclonal
• Specificity: This antibody is specific for SEMA 3B. Species Crossreactivity: This antibody reacts with mouse SEMA 3B protein. The immunogen used for this antibody production has 100% homology with human, 92% with mouse, 90% with Zebrafish, and 90% homology with human, mouse, and rat SEMA 3A protein. There is no significant homology with rat protein.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.

• Applicable Applications for anti-SEMA3B antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: A synthetic peptide made to an internal portion of the human SEMA 3B protein sequence (between residues 100-200).
• Cellular Localization: Secreted. Accumulates in the endoplasmic reticulum.
• Positive Control: Mouse E16 cerebellum lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-SEMA3B antibody

One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPI anchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. SEMA 3B inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Product Categories/Family for anti-SEMA3B antibody

Antibodies; Abs to Plexin; Semaphorin

NCBI and Uniprot Product Information

• NCBI GI #: 54607089
• NCBI GeneID: 7869
• NCBI Accession #: NP_001005914.1
• NCBI GenBank Nucleotide #: NM_001005914.1
• UniProt Accession #: Q13214; Q6GU46; Q8TB71; Q8TDV7; Q93018; Q96GX0; Q59FY7; Q6PI51; Q8NAS4; Q9HBR1
• Molecular Weight: 83,122 Da
• NCBI Official Full Name: semaphorin-3B isoform 2
• NCBI Official Synonym Full Names: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
• NCBI Official Symbol: SEMA3B
• NCBI Official Synonym Symbols: SemA; SEMA5; SEMAA; semaV; LUCA-1; FLJ34863
• NCBI Protein Information: semaphorin-3B; sema V; sema A(V); semaphorin A; semaphorin V; semaphorin-V; OTTHUMP00000233990; OTTHUMP00000233991
• UniProt Protein Name: Semaphorin-3B
• Protein Family: Semaphorin
• UniProt Gene Name: SEMA3B
• UniProt Synonym Gene Names: SEMA5; SEMAA
• UniProt Entry Name: SEM3B_HUMAN

NCBI Description

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis. [provided by RefSeq]

Uniprot Description

SEMA3B: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Expressed abundantly but differentially in a variety of neural and nonneural tissues. Belongs to the semaphorin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: membrane; endoplasmic reticulum

Molecular Function: receptor activity

Biological Process: axon guidance; cell-cell signaling