Goat anti-Human Retinoic Acid Receptor Responder 1 Polyclonal Antibody | anti-RARRES1 antibody

Retinoic Acid Receptor Responder 1 (RARRES1, Tig1)

Cat. Num. AAA622759

• Gene Names: RARRES1; TIG1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Retinoic Acid Receptor Responder 1; Polyclonal Antibody; Retinoic Acid Receptor Responder 1 (RARRES1; Tig1); Anti -Retinoic Acid Receptor Responder 1 (RARRES1; anti-RARRES1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RARRES1 extracellular domain.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.

• Applicable Applications for anti-RARRES1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 0.5-1.0ug/ml; Western Blot: 1.0ug/ml
• Immunogen: Recombinant human RARRES1 isoform 2 extracellular domain aa43-294; P49788 (E. coli)
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

SDS-Page

(Detection of RARRES1. Tissue lysates were resolved by SDS-PAGE, transferred to an Immobilon-P membrane and immunoblotted with 1.0ug/ml goat anti-hRARRES1.)

Related Product Information for anti-RARRES1 antibody

RARRES1 (retinoic acid receptor responder 1; also Tig1) is a member of the protease inhibitor I47 family of proteins. It is expressed in epithelium, including keratinocytes, plus prostate and breast epithelium. It is considered to be a tumor-suppressor molecule, presumably acting as an inhibitor of carboxypeptidase A. Human RARRES1 is 294aa in length. It is a type II transmembrane (TM) protein with a TM segment between aa21-42. Three potential splice variants exist. There is a 46aa N-terminal extension, a four aa substitution for aa225-294 and a combination of these two variants. Over aa43-294, human RARRES1 shares 75% aa identity with human RARRES1.

Product Categories/Family for anti-RARRES1 antibody

Antibodies; Abs to Protease Inhibitors

NCBI and Uniprot Product Information

• NCBI GI #: 46255043
• NCBI GeneID: 5918
• NCBI Accession #: NP_996846.1
• NCBI GenBank Nucleotide #: NM_206963.1
• UniProt Accession #: P49788; Q8N1D7
• Molecular Weight: 33,285 Da
• NCBI Official Full Name: retinoic acid receptor responder protein 1 isoform 1
• NCBI Official Synonym Full Names: retinoic acid receptor responder (tazarotene induced) 1
• NCBI Official Symbol: RARRES1
• NCBI Official Synonym Symbols: TIG1
• NCBI Protein Information: retinoic acid receptor responder protein 1; OTTHUMP00000213561; OTTHUMP00000213562; OTTHUMP00000213563; RAR-responsive protein TIG1; tazarotene-induced gene 1 protein
• UniProt Protein Name: Retinoic acid receptor responder protein 1
• Protein Family: Retinoic acid receptor responder protein
• UniProt Gene Name: RARRES1
• UniProt Synonym Gene Names: TIG1
• UniProt Entry Name: TIG1_HUMAN

NCBI Description

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq]

Uniprot Description

RARRES1: identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q25.32

Cellular Component: integral to membrane

Biological Process: negative regulation of cell proliferation