Rabbit anti-Human p53-associated Parkin-like Cytoplasmic Protein Polyclonal Antibody | anti-CUL9 antibody
p53-associated Parkin-like Cytoplasmic Protein (PARC)
Gene Names
CUL9; PARC; H7AP1; RP3-330M21.2; DKFZp686G1042; DKFZp686P2024; CUL9
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
p53-associated Parkin-like Cytoplasmic Protein; Polyclonal Antibody; p53-associated Parkin-like Cytoplasmic Protein (PARC); Anti -p53-associated Parkin-like Cytoplasmic Protein (PARC); anti-CUL9 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
Recognizes human p53-associated Parkin-like Cytoplasmic Protein
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Applicable Applications for anti-CUL9 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Dilution: ELISA: 1:250
Western Blot: 1:1000
Western Blot: 1:1000
Immunogen
Synthetic peptide (FFFGDEEEDEDEAYD) corresponding to aa2503-2517 of human PARC
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-CUL9 antibody
P53-associated parkin-like cytoplasmic protein (PARC) is a 270kD protein that acts as a cytoplasmic anchor for p53 unstressed cells, thereby regulating the localization and subsequent function of p53. It contains a cullin domain and a RING-IBR-RING domain at the carboxy terminus and it is ubiquitously expressed.
Product Categories/Family for anti-CUL9 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
281,229 Da
NCBI Official Full Name
p53-associated parkin-like cytoplasmic protein
NCBI Official Synonym Full Names
cullin 9
NCBI Official Symbol
CUL9
NCBI Official Synonym Symbols
PARC; H7AP1; RP3-330M21.2; DKFZp686G1042; DKFZp686P2024; CUL9
NCBI Protein Information
cullin-9; CUL-9; OTTHUMP00000217056; UbcH7-associated protein 1; parkin-like cytoplasmic p53 binding protein; p53-associated parkin-like cytoplasmic protein
UniProt Protein Name
Cullin-9
Protein Family
UniProt Gene Name
CUL9
UniProt Synonym Gene Names
H7AP1; KIAA0708; PARC
UniProt Entry Name
CUL9_HUMAN
Uniprot Description
PARC: Cytoplasmic anchor protein in p53-associated protein complex. Regulates the subcellular localization of p53 and subsequent function. Seems to be part of an atypical cullin-RING- based E3 ubiquitin-protein ligase complex. In vitro, complexes of CUL9/PARC with either CUL7 or TP53 contain E3 ubiquitin-protein ligase activity. Belongs to the cullin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase; Ligase
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cullin-RING ubiquitin ligase complex; cytoplasm
Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; ATP binding
Biological Process: ubiquitin-dependent protein catabolic process; regulation of mitosis; protein ubiquitination; microtubule cytoskeleton organization and biogenesis
Research Articles on CUL9
1. Observational study of gene-disease association. (HuGE Navigator)
2. These studies suggest that PARC-interacting peptides are promising candidates for the enhancement of p53-dependent apoptosis in tumors with wt cytoplasmic p53.
3. PARC and CUL7 subcomplexes exhibit E3 ubiquitin ligase activity in vitro.
4. FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2
5. CPH domain interaction surface of p53 resides in the tetramerization domain and is formed by residues contributed by at least two subunits
6. Parc, a Parkin-like ubiquitin ligase,is a critical regulator in controlling p53 subcellular cytoplasmic localization and subsequent function.
2. These studies suggest that PARC-interacting peptides are promising candidates for the enhancement of p53-dependent apoptosis in tumors with wt cytoplasmic p53.
3. PARC and CUL7 subcomplexes exhibit E3 ubiquitin ligase activity in vitro.
4. FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2
5. CPH domain interaction surface of p53 resides in the tetramerization domain and is formed by residues contributed by at least two subunits
6. Parc, a Parkin-like ubiquitin ligase,is a critical regulator in controlling p53 subcellular cytoplasmic localization and subsequent function.
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Product Notes
The CUL9 cul9 (Catalog #AAA619655) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The p53-associated Parkin-like Cytoplasmic Protein (PARC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's p53-associated Parkin-like Cytoplasmic Protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Dilution: ELISA: 1:250 Western Blot: 1:1000. Researchers should empirically determine the suitability of the CUL9 cul9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "p53-associated Parkin-like Cytoplasmic Protein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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