Rabbit anti-Human Unc-112-related protein 1 Polyclonal Antibody | anti-Fit1 antibody
Unc-112-related protein 1 (URP1, Kindlin-1, Kindlerin)
Gene Names
Fit1; anon-WO0118547.421; CG14991; DmelCG14991
Reactivity
Human
Applications
Western Blot
Purity
Affinity PurifiedPurified by affinity chromatography.
Synonyms
Unc-112-related protein 1; Polyclonal Antibody; Unc-112-related protein 1 (URP1; Kindlin-1; Kindlerin); Anti -Unc-112-related protein 1 (URP1; anti-Fit1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human URP1 at ~77kD. Reacts with aa643-660 of URP1. Species Sequence Homology (100%): mouse, rat, canine, bovine, chimpanzee and Xenopus
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Purified by affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Applicable Applications for anti-Fit1 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000
Dilution: Western Blot: 1:1000
Immunogen
Peptide corresponding to aa643-660, VHEYIGGYIFLSTRSKDQ of human Unc-112-related protein 1 (URP1).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-Fit1 antibody
Due to a concerted effort to identify biomarkers for lung and colon carcinomas by genome-wide transcriptional profiling, the identification and cloning of one such gene as well as two additional closely related genes was achieved. Due to the strong sequence homology to the C. elegans UNC-112 a novel gene gene was named URP1, for UNC-112 related protein. Another novel related gene, URP2 and the previously discovered MIG-2 gene was also identified. Transcriptional analysis shows that only URP1 is significantly differentially regulated, being over- expressed in 70% of the colon carcinomas and 60% of the lung carcinomas tested. Quantification of URP1 expression by qRT-PCR showed up-regulation of the gene by 60-fold in lung tumors and up to nearly 6-fold in colon tumors. Northern blot analysis of URP1 indicates that normal expression is restricted to neuromuscular tissues. In contrast, the expression of URP2 appears to be confined primarily to tissues of the immune system. URP1 has the potential to be one of the most important prognostic and markers of colon or lung cancer.
Product Categories/Family for anti-Fit1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
80,497 Da
NCBI Official Full Name
Unc-112-related protein
NCBI Official Synonym Full Names
Fermitin 1
NCBI Official Symbol
Fit1
NCBI Official Synonym Symbols
anon-WO0118547.421; CG14991; DmelCG14991
NCBI Protein Information
CG14991 gene product from transcript CG14991-RA; fermitin 1, isoform A; CG14991-PA; Fit1-PA; fermitin 1, isoform B; CG14991-PB; Fit1-PB
UniProt Protein Name
Unc-112-related protein
Protein Family
UniProt Gene Name
Fit1
UniProt Entry Name
UN112_DROME
Uniprot Description
Function: Probably involved in cell adhesion
Subcellular location: Cytoplasm
Probable.
Domain: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
Sequence similarities: Belongs to the kindlin family.Contains 1 FERM domain.Contains 1 PH domain.
Sequence caution: The sequence AAL28401.1 differs from that shown. Reason: Erroneous initiation.
Similar Products
Product Notes
The Fit1 fit1 (Catalog #AAA618393) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Unc-112-related protein 1 (URP1, Kindlin-1, Kindlerin) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Unc-112-related protein 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1:1000. Researchers should empirically determine the suitability of the Fit1 fit1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Unc-112-related protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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