anti-Human Cachectic Factor Polyclonal Antibody
Anti - Cachectic Factor (CF)
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Serum
Synonyms
Cachectic Factor; Polyclonal Antibody; Anti - Cachectic Factor (CF); Cachectic Factor (CF); anti-Cachectic Factor antibody
Host
Host: Rabbit
Source: Human
Source: Human
Reactivity
Human
Clonality
Polyclonal
Specificity
Recognizes human Cachetic factor (CF) protein.
Purity/Purification
Serum
Form/Format
Serum
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Applicable Applications for anti-Cachectic Factor antibody
ELISA, Western Blot
Application Notes
Suitable for use in ELISA and Western Blot. Other applications not tested.
Dilution: Western Blot: 1:500-1:2000 (ECL)
ELISA: 1:10,000-1:50,000 Control peptide can be used to coat ELISA plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Dilution: Western Blot: 1:500-1:2000 (ECL)
ELISA: 1:10,000-1:50,000 Control peptide can be used to coat ELISA plates at 1ug/ml.
Optimal dilutions to be determined by the researcher.
Immunogen
Purified urinary human Cachectic factor (CF) protein
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Cachectic Factor antibody
Cancer cachexia is a syndrome of progressive wasting which is believed to be mediated by tumor necrosis factor-alpha, interleukins 1 and 6, and interferon-gamma, and leukemia-inhibitory factor. However, the levels of these putative agents do not correlate with cachexia. Recently, a new circulating tumor factor, termed cachectic factor (CF), has been isolated and characterized from the urine of mice transplanted with adenocarcinoma MAC16 (1). Purified CF, a proteoglycan of relative mol. Wt of ~24kD, produces cachexia in vivo by inducing catabolism of skeletal muscle. CF was also found in urine of cachectic cancer patients. It is not found in normal urine, patient with weight loss due to trauma, and cancer patient with no weight loss (1).
Product Categories/Family for anti-Cachectic Factor antibody
References
• Todorov P et al (1996) Nature 379, 739-742; Todorov PT et al (1997) J. Biol. Chem. 272, 12279; Cariuk P et al (1997) Br. J. Cancer 76, 606-613; Cancer Res. (1995) 55, 1458-1563. Yoshizawa N et al (1992) J Immunol. 148, 3110-3116..
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Product Notes
The Cachectic Factor (Catalog #AAA618038) is an Antibody produced from Host: Rabbit Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti - Cachectic Factor (CF) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cachectic Factor can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot. Suitable for use in ELISA and Western Blot. Other applications not tested. Dilution: Western Blot: 1:500-1:2000 (ECL) ELISA: 1:10,000-1:50,000 Control peptide can be used to coat ELISA plates at 1ug/ml. Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the Cachectic Factor for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cachectic Factor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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