Rabbit anti-Human FOXI1a Polyclonal Antibody | anti-foxi4.2-a antibody

FOXI1a (Forkhead Box I1a, FKHL10, Forkhead-Related Transcription Factor 6, FREAC6, HNF-3 Forkhead Homolog 3, HFH3)

Cat. Num. AAA617999

• Gene Names: foxi4.2-a; xfd2; XFD2'; foxi1a; foxi4.2; MGC83274
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FOXI1a; Polyclonal Antibody; FOXI1a (Forkhead Box I1a; FKHL10; Forkhead-Related Transcription Factor 6; FREAC6; HNF-3 Forkhead Homolog 3; HFH3); Anti -FOXI1a (Forkhead Box I1a; anti-foxi4.2-a antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FOXI1a.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-foxi4.2-a antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Immunohistochemistry and Western Blot.; Dilution: ELISA Titer:1:250,000.; Western Blot: 1ug/ml. Band detected at 40kD using 293 cell lines and at 65kD using human colon.; Immunohistochemistry: 10ug/ml
• Immunogen: Synthetic peptide (KRKSDVSSSTASLAL-C) CORRESPONDING TO HUMAN FOXH1A (KLH). Molecular Weight: 41.3KD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-foxi4.2-a antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 147906729
• NCBI GeneID: 397954
• NCBI Accession #: NP_001081617.1
• NCBI GenBank Nucleotide #: NM_001088148.1
• UniProt Accession #: Q91904; Q68F03
• Molecular Weight: 41,388 Da
• NCBI Official Full Name: forkhead box protein I1-A
• NCBI Official Synonym Full Names: forkhead box I4, gene 2
• NCBI Official Symbol: foxi4.2-a
• NCBI Official Synonym Symbols: xfd2; XFD2'; foxi1a; foxi4.2; MGC83274
• NCBI Protein Information: forkhead box protein I1-A; xFD-2; foxI1-A; xFoxI1a; fork head domain-related protein 2
• UniProt Protein Name: Forkhead box protein I1-A
• UniProt Gene Name: foxi1-a
• UniProt Entry Name: FXI1A_XENLA

Uniprot Description

Function: Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the non-neural versus neural cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site. Ref.4 Ref.6

Subcellular location: Nucleus Ref.5.

Tissue specificity: Initially localized to the animal hemisphere (the presumptive ectoderm) of early-mid blastula embryos. Becomes restricted to head placodes, excluding the otic placodes, by the tailbud stages. Ref.1 Ref.5 Ref.6

Developmental stage: Expression begins at the early-mid blastula stage. Levels are highest during the blastula and gastrula stages, after which levels decreases until somite segregation. At later developmental stages, expressed at a slightly lower level than foxi1-B. Ref.1 Ref.5 Ref.6

Induction: Induced by Bmp-signaling. Suppressed by Wnt-signaling. Ref.5 Ref.6

Sequence similarities: Contains 1 fork-head DNA-binding domain.

Sequence caution: The sequence AAH80044.1 differs from that shown. Reason: Erroneous initiation.