Rabbit Taurine Transporter Polyclonal Antibody | anti-SLC6A6 antibody

Taurine Transporter (Tau1, TauT)

Cat. Num. AAA616946

• Gene Names: SLC6A6; TAUT; MGC10619; MGC131729
• Reactivity: Canine, Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Taurine Transporter; Polyclonal Antibody; Taurine Transporter (Tau1; TauT); Anti -Taurine Transporter (Tau1; anti-SLC6A6 antibody

• Host: Rabbit
• Reactivity: Canine, Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes Taurine Transporter ~65-70kD. The immunogen shows 100% sequence homology with mouse and 90% with human and canine.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.1% BSA and 0.05% sodium azide.

• Applicable Applications for anti-SLC6A6 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:10,000-1:100,000; Western Blot: 1-10ug/ml (ECL); Optimal dilutions to be determined by the researcher.
• Immunogen: A 20 amino acid peptide near the carboxy terminal cytoplasmic region of rat Taurine Transporter (1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-SLC6A6 antibody

Antibodies; Abs to Transport Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 799339
• NCBI GeneID: 6533
• UniProt Accession #: P31641; Q9BXB0; Q59GD7; Q9BRI2; AAB25509
• Molecular Weight: 69,830 Da
• NCBI Official Full Name: taurine transporter
• NCBI Official Synonym Full Names: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
• NCBI Official Symbol: SLC6A6
• NCBI Official Synonym Symbols: TAUT; MGC10619; MGC131729
• NCBI Protein Information: sodium- and chloride-dependent taurine transporter; OTTHUMP00000208177; OTTHUMP00000208180; solute carrier family 6 member 6
• UniProt Protein Name: Sodium- and chloride-dependent taurine transporter
• Protein Family: Sodium- and chloride-dependent taurine transporter
• UniProt Gene Name: SLC6A6
• UniProt Entry Name: SC6A6_HUMAN

NCBI Description

Taurine (2-aminoethanesulfonic acid) is a major intracellular amino acid in mammals. It is involved in a number of important physiologic processes, including bile acid conjugation in hepatocytes, modulation of calcium flux and neural excitability, osmoregulation, detoxification, and membrane stabilization. The cells of most organisms respond to hypertonicity by the intracellular accumulation of high concentrations of small organic solutes (osmolytes) that, in contrast to high concentrations of electrolytes, do not perturb the function of macromolecules. The renal medulla is normally the only tissue in mammals that undergoes wide shifts in tonicity. Its hypertonicity when the kidney is excreting a concentrated urine is fundamental to water conservation. The taurine content of the renal medulla of rats infused with 5% NaCl is higher than that in controls, suggesting that taurine behaves as an osmolyte in the renal medulla. Indeed, taurine functions as an osmolyte in Madin-Darby canine kidney (MDCK) cells. When MDCK cells cultured in isotonic medium are switched to hypertonic medium, their content of taurine doubles through the taking up of taurine from the medium. Taurine transport in these cells is dependent on sodium and chloride ions and is localized primarily in the basolateral plasma membrane (summary by Uchida et al., 1992 [PubMed 1518851]).[supplied by OMIM]

Uniprot Description

TAUT: Required for the uptake of taurine. Transports both taurine and beta-alanine which requires sodium ions. Chloride ions are necessary for optimal uptake. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: taurine binding; neurotransmitter:sodium symporter activity; taurine:sodium symporter activity

Biological Process: amino acid metabolic process; taurine transport; amino acid transport; neurotransmitter transport; transport; ion transport; transmembrane transport