Rabbit Opa1 Polyclonal Antibody | anti-OPA1 antibody

Opa1 (Optic Atrophy 1, Optic Atrophy 1 Gene Protein, Optic Atrophy Protein 1, Dynamin-like 120kD Protein)

Cat. Num. AAA616469

• Gene Names: OPA1; NPG; NTG; MGM1; largeG; FLJ12460; KIAA0567
• Reactivity: Chicken, Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Opa1; Polyclonal Antibody; Opa1 (Optic Atrophy 1; Optic Atrophy 1 Gene Protein; Optic Atrophy Protein 1; Dynamin-like 120kD Protein); Anti -Opa1 (Optic Atrophy 1; anti-OPA1 antibody

• Host: Rabbit
• Reactivity: Chicken, Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Species Crossreactivity: This antibody reacts with the human protein. It has not been tested against any other species.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.

• Applicable Applications for anti-OPA1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.
• Immunogen: A synthetic peptide made to an internal region within residues 500-600 of the human protein. [Swiss-Prot# O60313]. Homology: 100% human, mouse, rat, and chicken
• Cellular Localization: Mitochondrion; mitochondrial inner membrane; single-pass membrane protein. Mitochondrion; mitochondrial intermembrane space.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-OPA1 antibody

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Eight transcript variants encoding different isoforms, resulting from alternative splicing of exon 4 and two novel exons named 4b and 5b, have been reported for this gene.

Product Categories/Family for anti-OPA1 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 34783689
• NCBI GeneID: 4976
• UniProt Accession #: Q6PEK6; O60313
• Molecular Weight: 33,060 Da
• NCBI Official Full Name: OPA1 protein
• NCBI Official Synonym Full Names: optic atrophy 1 (autosomal dominant)
• NCBI Official Symbol: OPA1
• NCBI Official Synonym Symbols: NPG; NTG; MGM1; largeG; FLJ12460; KIAA0567
• NCBI Protein Information: dynamin-like 120 kDa protein, mitochondrial; OTTHUMP00000195064; OTTHUMP00000195065; optic atrophy protein 1; mitochondrial dynamin-like GTPase; mitochondrial dynamin-like 120 kDa protein
• UniProt Protein Name: OPA1 protein
• Protein Family: Dynamin-like 120 kDa protein
• UniProt Entry Name: Q6PEK6_HUMAN

NCBI Description

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Hydrolase; EC 3.6.5.5; Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrial crista; membrane; mitochondrion; mitochondrial inner membrane; dendrite; cytoplasm; integral to membrane; mitochondrial intermembrane space

Molecular Function: GTPase activity; protein binding; GTP binding; magnesium ion binding

Biological Process: inner mitochondrial membrane organization and biogenesis; mitochondrion organization and biogenesis; mitochondrial fission; mitochondrial genome maintenance; axon transport of mitochondrion; visual perception; mitochondrial fusion; apoptosis; metabolic process; neural tube closure

Disease: Glaucoma, Normal Tension, Susceptibility To; Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy; Optic Atrophy 1