Rabbit Cyclic Nucleotide-gated Channel 1 Polyclonal Antibody | anti-tax-4 antibody
Cyclic Nucleotide-gated Channel 1 (CNG1)
Reactivity
Human, Porcine
Applications
ELISA, Western Blot
Purity
Affinity PurifiedAffinity purified Ig
Synonyms
Cyclic Nucleotide-gated Channel 1; Polyclonal Antibody; Cyclic Nucleotide-gated Channel 1 (CNG1); Anti -Cyclic Nucleotide-gated Channel 1 (CNG1); anti-tax-4 antibody
Host
Rabbit
Reactivity
Human, Porcine
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human Cyclic Nucleotide-Gated Channel 1 (CNG1). The immunogen shows no significant sequence homology with other CNGs. Species Crossreactivity: Human. The immunogen sequence is 100% conserved in porcine, 80% in bovine, 70% in canine and 57% in rat.
Purity/Purification
Affinity Purified
Affinity purified Ig
Affinity purified Ig
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% BSA and 0.1% sodium azide.
Applicable Applications for anti-tax-4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Western blot: 1-10ug/ml using ECL. Immunohistochemistry: not tested. It is recommended that the antibody be tried at 1-20ug/ml on paraformaldehyde fixed tissue. ELISA: 0.5-1ug/ml using 1ug/ml control peptide per well.
Immunogen
A 20 amino acid peptide sequence near the N-terminus of human CNG1 (1).
Preparation and Storage
-20 degree C
Product Categories/Family for anti-tax-4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
83,893 Da
NCBI Official Full Name
cyclic nucleotide-gated channel
NCBI Official Symbol
tax-4
NCBI Protein Information
abnormal CHEmotaxis family member (tax-4)
UniProt Protein Name
Cyclic nucleotide-gated cation channel
UniProt Gene Name
tax-4
UniProt Entry Name
CNG_CAEEL
Uniprot Description
Function: Required for normal thermosensation and chemosensation sensory behavior. Ref.1
Subcellular location: Membrane; Multi-pass membrane protein
Probable.
Tissue specificity: Expressed at the sensory endings of thermosensory, gustatory, and olfactory neurons.
Sequence similarities: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. [View classification]Contains 1 cyclic nucleotide-binding domain.
Research Articles on tax-4
1. By recording from the C. elegans thermosensory neurons AFD in vivo, we found that ion channels TAX-2 and TAX-4 are involved in temperature sensing by a cGMP-mediated pathway
2. Wild-type worms are induced to display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium; this was abolished in chemotaxis-defective tax-4 mutants.
3. Mutants in tax-4 showed abnormal thermal responses, suggesting that these genes are involved in warm avoidance.
2. Wild-type worms are induced to display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium; this was abolished in chemotaxis-defective tax-4 mutants.
3. Mutants in tax-4 showed abnormal thermal responses, suggesting that these genes are involved in warm avoidance.
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Product Notes
The tax-4 tax-4 (Catalog #AAA616337) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cyclic Nucleotide-gated Channel 1 (CNG1) reacts with Human, Porcine and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclic Nucleotide-gated Channel 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Western blot: 1-10ug/ml using ECL. Immunohistochemistry: not tested. It is recommended that the antibody be tried at 1-20ug/ml on paraformaldehyde fixed tissue. ELISA: 0.5-1ug/ml using 1ug/ml control peptide per well. Researchers should empirically determine the suitability of the tax-4 tax-4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclic Nucleotide-gated Channel 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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