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Western Blot (WB) (Western Blot analysis of PTX3 expression in PC-12.)

Mouse anti-Human, Rat PTX3 Monoclonal Antibody | anti-PTX3 antibody

PTX3 (Pentraxin-related Protein PTX3, Pentaxin-related Protein PTX3, Tumor Necrosis Factor alpha-induced Protein 5, TNF alpha-induced Protein 5, Tumor Necrosis Factor-inducible Gene 14 Protein, TSG-14, TNFAIP5, TSG14) (PE)

Gene Names
PTX3; TSG-14; TNFAIP5
Reactivity
Human, Rat
Applications
Immunofluorescence, Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
PTX3; Monoclonal Antibody; PTX3 (Pentraxin-related Protein PTX3; Pentaxin-related Protein PTX3; Tumor Necrosis Factor alpha-induced Protein 5; TNF alpha-induced Protein 5; Tumor Necrosis Factor-inducible Gene 14 Protein; TSG-14; TNFAIP5; TSG14) (PE); anti-PTX3 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human, Rat
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2B10
Specificity
Recognizes human PTX3. Species crossreactivity: rat
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Applicable Applications for anti-PTX3 antibody
FLISA, Immunofluorescence (IF), Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Partial recombinant protein corresponding to aa282-380 from human PTX3 with GST tag. MW of the GST tag alone is 26kD.
Immunogen Sequence
SLWVNGELAATTVEMATGHIVPEGGILQIGQEKNGCCVGGGFDETLAFSGRLTGFNIWDSVLSNEEIRETGGAESCHIRGNIVGWGVTEIQPHGGAQYV
Conjugate
PE
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PTX3 expression in PC-12.)

Western Blot (WB) (Western Blot analysis of PTX3 expression in PC-12.)

Western Blot (WB)

(Western Blot analysis of PTX3 expression in U-2 OS.)

Western Blot (WB) (Western Blot analysis of PTX3 expression in U-2 OS.)

Testing Data

(Detection limit for recombinant GST tagged PTX3 is ~0.03ng/ml as a capture antibody using 252613.)

Testing Data (Detection limit for recombinant GST tagged PTX3 is ~0.03ng/ml as a capture antibody using 252613.)

Immunofluorescence (IF)

(Immunofluorescence of 132096 on HeLa cell. [10ug/ml])

Immunofluorescence (IF) (Immunofluorescence of 132096 on HeLa cell. [10ug/ml])
Related Product Information for anti-PTX3 antibody
PITX3 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development.
Product Categories/Family for anti-PTX3 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42kDa
NCBI Official Full Name
pentraxin-related protein PTX3
NCBI Official Synonym Full Names
pentraxin 3
NCBI Official Symbol
PTX3
NCBI Official Synonym Symbols
TSG-14; TNFAIP5
NCBI Protein Information
pentraxin-related protein PTX3
UniProt Protein Name
Pentraxin-related protein PTX3
Protein Family
UniProt Gene Name
PTX3
UniProt Synonym Gene Names
TNFAIP5; TSG14; TNF alpha-induced protein 5; TSG-14
UniProt Entry Name
PTX3_HUMAN

NCBI Description

This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions. [provided by RefSeq, Jun 2016]

Uniprot Description

PTX3: Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 3q25

Cellular Component: extracellular space; extracellular region

Molecular Function: complement component C1q binding; zymosan binding; virion binding

Biological Process: positive regulation of nitric oxide biosynthetic process; negative regulation of virion penetration into host cell; positive regulation of phagocytosis; innate immune response; response to yeast; opsonization; inflammatory response

Research Articles on PTX3

Similar Products

Product Notes

The PTX3 ptx3 (Catalog #AAA6159745) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PTX3 (Pentraxin-related Protein PTX3, Pentaxin-related Protein PTX3, Tumor Necrosis Factor alpha-induced Protein 5, TNF alpha-induced Protein 5, Tumor Necrosis Factor-inducible Gene 14 Protein, TSG-14, TNFAIP5, TSG14) (PE) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTX3 can be used in a range of immunoassay formats including, but not limited to, FLISA, Immunofluorescence (IF), Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PTX3 ptx3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTX3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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