Rabbit anti-Human Glucagon-like Peptide 2 Receptor Polyclonal Antibody | anti-GLP2R antibody

Glucagon-like Peptide 2 Receptor (GLP2R)

Cat. Num. AAA614220

• Gene Names: GLP2R; GLP2R
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Glucagon-like Peptide 2 Receptor; Polyclonal Antibody; Glucagon-like Peptide 2 Receptor (GLP2R); Anti -Glucagon-like Peptide 2 Receptor (GLP2R); anti-GLP2R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GLP2R. Species sequence homology: mouse-85%, rat-75%.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-GLP2R antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot and ELISA.; Dilution: Western Blot: 1-10ug/ml using Chemiluminescence technique.; ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml (See G2040-39H).
• Immunogen: Synthetic peptide, 20aa corresponding to mid-region, cytoplasmic of human GLP2R.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-GLP2R antibody

Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis. The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration.

Product Categories/Family for anti-GLP2R antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4758438
• NCBI GeneID: 9340
• NCBI Accession #: NP_004237.1
• NCBI GenBank Nucleotide #: NM_004246.1
• UniProt Accession #: O95838; Q4VAT3; Q4VAT1; Q4VAT2; Q4VAT4; Q86XI5; Q86YG9; Q8WUR8
• Molecular Weight: 63,001 Da
• NCBI Official Full Name: glucagon-like peptide 2 receptor
• NCBI Official Synonym Full Names: glucagon-like peptide 2 receptor
• NCBI Official Symbol: GLP2R
• NCBI Official Synonym Symbols: GLP2R
• NCBI Protein Information: glucagon-like peptide 2 receptor; GLP-2R; GLP-2-R; GLP-2 receptor; OTTHUMP00000160769
• UniProt Protein Name: Glucagon-like peptide 2 receptor
• Protein Family: Glucagon-like peptide 2 receptor
• UniProt Gene Name: GLP2R
• UniProt Entry Name: GLP2R_HUMAN

NCBI Description

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq]

Uniprot Description

GLP2R: This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; positive regulation of cell proliferation