Rabbit Biliverdin Reductase Polyclonal Antibody | anti-bvdR antibody

Biliverdin Reductase (BVR)

Cat. Num. AAA613920

• Reactivity: E Coli, Guinea Pig, Hamster, Mouse, Rat
• Applications: Western Blot, Immunoprecipitation
• Purity: Purified; Purified by ammonium sulfate precipitation.
• Synonyms: Biliverdin Reductase; Polyclonal Antibody; Biliverdin Reductase (BVR); Anti -Biliverdin Reductase (BVR); anti-bvdR antibody

• Host: Rabbit
• Reactivity: E Coli, Guinea Pig, Hamster, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Detects an ~41-42kD protein (human) and ~33kD protein (rat), corresponding to the apparent molecular mass of Biliverdin Reductase on SDS-PAGE Western Blots.
• Purity/Purification: Purified; Purified by ammonium sulfate precipitation.
• Form/Format: Supplied as a liquid in PBS, 0.1mM PMSF, 50% glycerol.

• Applicable Applications for anti-bvdR antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blotting, Immunoprecipitation.; Dilution: Western Blotting: 1:5000; Immunoprecipitation: 1:100
• Immunogen: Recombinant rat Biliverdin Reductase expressed in E. coli.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-bvdR antibody

Cleavage of heme b (Fe-protoporphyrin IX) at the alpha-methene carbon bridge to form the open tetrapyrrole, biliverdin IXa and carbon monoxide (CO) is catalyzed by heme oxygenase (HO) isozymes HO- 1 and HO-2 (heme hydrogen-donor: oxygen oxidoreductase; EC 1.14.99.3). In mammalian species biliverdin reductase (BVR; bilirubin: NAD(P)+ oxidoreductase; EC 1.3.1.24) converts the open tetrapyrrole to bilirubin. This pathway is the only efficient way of making bilirubin and hence deterring activation of oxygen by the heme molecule. The two isozymes of heme oxygen, one of which is referred to as HO-1, is a member of the heat shock protein family (Hsp32), and the second, or HO-2, is a constitutive form and is expressed at exceedingly high levels in the brain and testes. The end products of the heme degradation process have important physiological activities. CO is suspected of being a potential messenger in the brain and systemic organs wherein by interacting with the heme-dependent form of guanylate cyclase it stimulates cGMP-production. Bile pigments have been demonstrated to display potent antioxidant activity and have effective antiviral activity against HIV and herpes virus. BVR is unique among all enzymes characterized to date in having two pH optima (6.8 and 8.7), using a different cofactor at each pH range (NADH at pH 7.0 and NADPH at pH 8.7). The enzyme displays pI and molecular mass microheterogeneity which appear to be a result of post translational modifications. In rat the enzyme also shows a tissue specific developmental pattern. BVR is not a inactivated by heat shock and its preexisting message is not sequestered from translation subsequent to thermal stress. Furthermore, the microheterogeneity of the reductase

Product Categories/Family for anti-bvdR antibody

Antibodies; Abs to Enzymes; Reductase

NCBI and Uniprot Product Information

• NCBI GI #: 37520419
• NCBI GeneID: 2599276
• NCBI Accession #: NP_923796.1
• NCBI GenBank Nucleotide #: NC_005125.1
• NCBI Official Full Name: biliverdin reductase
• NCBI Official Symbol: bvdR
• NCBI Protein Information: biliverdin reductase
• Protein Family: Biliverdin reductase