Rabbit anti-Human Synuclein, gamma CT Polyclonal Antibody
Synuclein, gamma CT (BCSG1, SYN)
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity PurifiedPurified by affinity chromatography.
Synonyms
Synuclein; gamma CT; Polyclonal Antibody; gamma CT (BCSG1; SYN); Anti -Synuclein; anti-Synuclein; gamma CT antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human gamma-synuclein. No significant sequence homology with alpha- or beta-synucleins, or other proteins. Species Sequence Homology: No significant sequence homology is seen with either rat/mouse gamma-synuclein.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Purified by affinity chromatography.
Form/Format
Supplied as a lyophilized powder in 100mM Tris, pH 7.5, 0.2% BSA, 0.1% sodium azide.
Applicable Applications for anti-Synuclein, gamma CT antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA, Western Blot.
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well
Western Blot: 1-10 ug/ml using Chemiluminescence technique
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well
Western Blot: 1-10 ug/ml using Chemiluminescence technique
Immunogen
Synthetic peptide17aa near the C-terminus of human g-synuclein (KLH coupled).
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-Synuclein, gamma CT antibody
Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid 1-40, 1-42 and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140aa a-synucleins is identical with non-Ab component (NACP) of AD. The 134aa b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine has the potential to cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms, two large (140aa SYN-1 & 149aa SYN-2) and a small form (SYN-3, 42aa) are produced by alternative splicing. Recently a new isoform, termed g-synuclein (SNCG) or breast cancer gene 1 (BCG1) has been cloned (human 127aa, rat/mouse 123aa). All three synucleins shown ~40% identity. g-synuclein is primarily expressed in brain (substantia nigra), and over expressed in advanced infiltrating carcinoma of breast, and in ovarian cancer.
Product Categories/Family for anti-Synuclein, gamma CT antibody
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Product Notes
The Synuclein, gamma CT (Catalog #AAA613795) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Synuclein, gamma CT (BCSG1, SYN) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Synuclein, gamma CT can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA, Western Blot. Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well Western Blot: 1-10 ug/ml using Chemiluminescence technique. Researchers should empirically determine the suitability of the Synuclein, gamma CT for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Synuclein, gamma CT, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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